PepPSy: a web server to prioritize gene products in experimental and biocuration workflows

Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein...

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Detalles Bibliográficos
Autores principales: Sallou, Olivier, Duek, Paula D., Darde, Thomas A., Collin, Olivier, Lane, Lydie, Chalmel, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865363/
https://www.ncbi.nlm.nih.gov/pubmed/27173522
http://dx.doi.org/10.1093/database/baw070
Descripción
Sumario:Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the ‘omics’ data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.org. Database URL: http://peppsy.genouest.org.

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