PepPSy: a web server to prioritize gene products in experimental and biocuration workflows

Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein...

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Detalles Bibliográficos
Autores principales: Sallou, Olivier, Duek, Paula D., Darde, Thomas A., Collin, Olivier, Lane, Lydie, Chalmel, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865363/
https://www.ncbi.nlm.nih.gov/pubmed/27173522
http://dx.doi.org/10.1093/database/baw070
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author Sallou, Olivier
Duek, Paula D.
Darde, Thomas A.
Collin, Olivier
Lane, Lydie
Chalmel, Frédéric
author_facet Sallou, Olivier
Duek, Paula D.
Darde, Thomas A.
Collin, Olivier
Lane, Lydie
Chalmel, Frédéric
author_sort Sallou, Olivier
collection PubMed
description Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the ‘omics’ data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.org. Database URL: http://peppsy.genouest.org.
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spelling pubmed-48653632016-05-13 PepPSy: a web server to prioritize gene products in experimental and biocuration workflows Sallou, Olivier Duek, Paula D. Darde, Thomas A. Collin, Olivier Lane, Lydie Chalmel, Frédéric Database (Oxford) Original Article Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the ‘omics’ data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.org. Database URL: http://peppsy.genouest.org. Oxford University Press 2016-05-12 /pmc/articles/PMC4865363/ /pubmed/27173522 http://dx.doi.org/10.1093/database/baw070 Text en © The Author(s) 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sallou, Olivier
Duek, Paula D.
Darde, Thomas A.
Collin, Olivier
Lane, Lydie
Chalmel, Frédéric
PepPSy: a web server to prioritize gene products in experimental and biocuration workflows
title PepPSy: a web server to prioritize gene products in experimental and biocuration workflows
title_full PepPSy: a web server to prioritize gene products in experimental and biocuration workflows
title_fullStr PepPSy: a web server to prioritize gene products in experimental and biocuration workflows
title_full_unstemmed PepPSy: a web server to prioritize gene products in experimental and biocuration workflows
title_short PepPSy: a web server to prioritize gene products in experimental and biocuration workflows
title_sort peppsy: a web server to prioritize gene products in experimental and biocuration workflows
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865363/
https://www.ncbi.nlm.nih.gov/pubmed/27173522
http://dx.doi.org/10.1093/database/baw070
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