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A clinically relevant pharmacokinetic interaction between cyclosporine and imatinib
PURPOSE: Cyclosporine A (CsA) and imatinib are both CYP3A4 and P-glycoprotein substrates. Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmac...
Autores principales: | Atiq, Ferdows, Broers, Annoek E C, Andrews, Louise M, Doorduijn, Jeanette K, Koch, Birgit C P, Van Gelder, Teun, Versmissen, Jorie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865545/ https://www.ncbi.nlm.nih.gov/pubmed/26965514 http://dx.doi.org/10.1007/s00228-016-2038-9 |
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