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Regulation of neuronal chloride homeostasis by neuromodulators
KCC2 is the central regulator of neuronal Cl(−) homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epileps...
Autores principales: | Mahadevan, Vivek, Woodin, Melanie A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865579/ https://www.ncbi.nlm.nih.gov/pubmed/26876607 http://dx.doi.org/10.1113/JP271593 |
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