Cargando…
Persistent HIV-1 replication maintains the tissue reservoir during therapy
Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site of viral production, storage of viral particles in immune complexes, and viral persistence. Whilst combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable...
Autores principales: | Lorenzo-Redondo, Ramon, Fryer, Helen R., Bedford, Trevor, Kim, Eun-Young, Archer, John, Pond, Sergei L. Kosakovsky, Chung, Yoon-Seok, Penugonda, Sudhir, Chipman, Jeffrey, Fletcher, Courtney V., Schacker, Timothy W., Malim, Michael H., Rambaut, Andrew, Haase, Ashley T., McLean, Angela R., Wolinsky, Steven M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865637/ https://www.ncbi.nlm.nih.gov/pubmed/26814962 http://dx.doi.org/10.1038/nature16933 |
Ejemplares similares
-
Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection
por: Kim, Eun-Young, et al.
Publicado: (2014) -
Increased T cell trafficking as adjunct therapy for HIV-1
por: Fryer, Helen R., et al.
Publicado: (2018) -
Phylodynamic Reconstruction Reveals Norovirus GII.4 Epidemic Expansions and their Molecular Determinants
por: Siebenga, J. Joukje, et al.
Publicado: (2010) -
Impact of Integrase Inhibition Compared With Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues
por: Rothenberger, Meghan, et al.
Publicado: (2019) -
Synonymous Substitution Rates Predict HIV Disease Progression as a Result of Underlying Replication Dynamics
por: Lemey, Philippe, et al.
Publicado: (2007)