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Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants

PURPOSE: To identify the effects of modified parenteral nutrition (PN) and enteral nutrition (EN) regimens on the growth of very low birth weight (VLBW) infants. METHODS: The study included VLBW infants weighing <1,500 g, admitted to Chungnam National University Hospital between October 2010 and...

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Autores principales: Choi, Ah Young, Lee, Yong Wook, Chang, Mea-young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pediatric Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865639/
https://www.ncbi.nlm.nih.gov/pubmed/27186226
http://dx.doi.org/10.3345/kjp.2016.59.4.165
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author Choi, Ah Young
Lee, Yong Wook
Chang, Mea-young
author_facet Choi, Ah Young
Lee, Yong Wook
Chang, Mea-young
author_sort Choi, Ah Young
collection PubMed
description PURPOSE: To identify the effects of modified parenteral nutrition (PN) and enteral nutrition (EN) regimens on the growth of very low birth weight (VLBW) infants. METHODS: The study included VLBW infants weighing <1,500 g, admitted to Chungnam National University Hospital between October 2010 and April 2014, who were alive at the time of discharge. Subjects were divided according to 3 periods: period 1 (n=37); prior to the PN and EN regimen being modified, period 2 (n=50); following the PN-only regimen modification, period 3 (n=37); following both PN and EN regimen modification. The modified PN regimen provided 3 g/kg/day of protein and 1 g/kg/day of lipid on the first day of life. The modified EN regimen provided 3.5-4.5 g/kg/day of protein and 150 kcal/kg/day of energy. We investigated growth rate, anthropometric measurements at 40 weeks postconceptional age (PCA) and the incidence of extrauterine growth restriction (EUGR) at 40 weeks PCA. RESULTS: Across the 3 periods, clinical characteristics, including gestational age, anthropometric measurements at birth, multiple births, sex, Apgar score, surfactant use and PDA treatment, were similar. Growth rates for weight and height, from time of full enteral feeding to 40 weeks PCA, were higher in period 3. Anthropometric measurements at 40 weeks PCA were greatest in period 3. Incidence of weight, height and head circumference EUGR at 40 weeks PCA decreased in period 3. CONCLUSION: Beginning PN earlier, with a greater supply of protein and energy during PN and EN, is advantageous for postnatal growth in VLBW infants.
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spelling pubmed-48656392016-05-16 Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants Choi, Ah Young Lee, Yong Wook Chang, Mea-young Korean J Pediatr Original Article PURPOSE: To identify the effects of modified parenteral nutrition (PN) and enteral nutrition (EN) regimens on the growth of very low birth weight (VLBW) infants. METHODS: The study included VLBW infants weighing <1,500 g, admitted to Chungnam National University Hospital between October 2010 and April 2014, who were alive at the time of discharge. Subjects were divided according to 3 periods: period 1 (n=37); prior to the PN and EN regimen being modified, period 2 (n=50); following the PN-only regimen modification, period 3 (n=37); following both PN and EN regimen modification. The modified PN regimen provided 3 g/kg/day of protein and 1 g/kg/day of lipid on the first day of life. The modified EN regimen provided 3.5-4.5 g/kg/day of protein and 150 kcal/kg/day of energy. We investigated growth rate, anthropometric measurements at 40 weeks postconceptional age (PCA) and the incidence of extrauterine growth restriction (EUGR) at 40 weeks PCA. RESULTS: Across the 3 periods, clinical characteristics, including gestational age, anthropometric measurements at birth, multiple births, sex, Apgar score, surfactant use and PDA treatment, were similar. Growth rates for weight and height, from time of full enteral feeding to 40 weeks PCA, were higher in period 3. Anthropometric measurements at 40 weeks PCA were greatest in period 3. Incidence of weight, height and head circumference EUGR at 40 weeks PCA decreased in period 3. CONCLUSION: Beginning PN earlier, with a greater supply of protein and energy during PN and EN, is advantageous for postnatal growth in VLBW infants. The Korean Pediatric Society 2016-04 2016-04-30 /pmc/articles/PMC4865639/ /pubmed/27186226 http://dx.doi.org/10.3345/kjp.2016.59.4.165 Text en Copyright © 2016 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Ah Young
Lee, Yong Wook
Chang, Mea-young
Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
title Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
title_full Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
title_fullStr Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
title_full_unstemmed Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
title_short Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
title_sort modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865639/
https://www.ncbi.nlm.nih.gov/pubmed/27186226
http://dx.doi.org/10.3345/kjp.2016.59.4.165
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