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Intraoperative indocyanine green angiography for the objective measurement of blood flow

PURPOSE: Intraoperative assessment of tissue perfusion is important to predict wound healing or improvement of symptoms in patients with peripheral arterial disease (PAD) or vascular trauma. There is no widely accepted standard for intraoperative measurement of tissue perfusion. Here, we report the...

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Autores principales: Joh, Jin Hyun, Park, Ho-Chul, Han, Sang-Ah, Ahn, Hyung Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865706/
https://www.ncbi.nlm.nih.gov/pubmed/27186573
http://dx.doi.org/10.4174/astr.2016.90.5.279
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author Joh, Jin Hyun
Park, Ho-Chul
Han, Sang-Ah
Ahn, Hyung Joon
author_facet Joh, Jin Hyun
Park, Ho-Chul
Han, Sang-Ah
Ahn, Hyung Joon
author_sort Joh, Jin Hyun
collection PubMed
description PURPOSE: Intraoperative assessment of tissue perfusion is important to predict wound healing or improvement of symptoms in patients with peripheral arterial disease (PAD) or vascular trauma. There is no widely accepted standard for intraoperative measurement of tissue perfusion. Here, we report the use of indocyanine green (ICG)-based angiography to determine the blood flow in patients with PAD and vascular trauma. METHODS: The SPY fluorescent imaging system was utilized. A dose of 3–5 mL of ICG (2.5 mg/mL) was injected intravenously followed by a 10 mL normal saline flush. The SPY imaging system was used to quantitatively assess perfusion. During the study period, the SPY imaging system was applied in 4 patients with PAD and one patient with vascular trauma. RESULTS: In 3 patients with PAD associated with an ischemic wound, complete wound healing was achieved with the indication of viable tissue by the SPY system. In one patient with severe claudication in both lower extremities, the ICG angiography was used to determine the increased blood flow after revascularization. In the case of vascular trauma, this imaging system enabled the delineation of viability of the injured tissue. CONCLUSION: ICG angiography can determine the surface tissue viability in PAD patients. In cases of severe vascular trauma,the SPY system can be used to determine tissue perfusion. Further study is warranted to define the definite utility of this technology to assess perfusion, response to revascularization, and potentially, to predict the likelihood of wound healing.
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spelling pubmed-48657062016-05-16 Intraoperative indocyanine green angiography for the objective measurement of blood flow Joh, Jin Hyun Park, Ho-Chul Han, Sang-Ah Ahn, Hyung Joon Ann Surg Treat Res Original Article PURPOSE: Intraoperative assessment of tissue perfusion is important to predict wound healing or improvement of symptoms in patients with peripheral arterial disease (PAD) or vascular trauma. There is no widely accepted standard for intraoperative measurement of tissue perfusion. Here, we report the use of indocyanine green (ICG)-based angiography to determine the blood flow in patients with PAD and vascular trauma. METHODS: The SPY fluorescent imaging system was utilized. A dose of 3–5 mL of ICG (2.5 mg/mL) was injected intravenously followed by a 10 mL normal saline flush. The SPY imaging system was used to quantitatively assess perfusion. During the study period, the SPY imaging system was applied in 4 patients with PAD and one patient with vascular trauma. RESULTS: In 3 patients with PAD associated with an ischemic wound, complete wound healing was achieved with the indication of viable tissue by the SPY system. In one patient with severe claudication in both lower extremities, the ICG angiography was used to determine the increased blood flow after revascularization. In the case of vascular trauma, this imaging system enabled the delineation of viability of the injured tissue. CONCLUSION: ICG angiography can determine the surface tissue viability in PAD patients. In cases of severe vascular trauma,the SPY system can be used to determine tissue perfusion. Further study is warranted to define the definite utility of this technology to assess perfusion, response to revascularization, and potentially, to predict the likelihood of wound healing. The Korean Surgical Society 2016-05 2016-05-02 /pmc/articles/PMC4865706/ /pubmed/27186573 http://dx.doi.org/10.4174/astr.2016.90.5.279 Text en Copyright © 2016, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Joh, Jin Hyun
Park, Ho-Chul
Han, Sang-Ah
Ahn, Hyung Joon
Intraoperative indocyanine green angiography for the objective measurement of blood flow
title Intraoperative indocyanine green angiography for the objective measurement of blood flow
title_full Intraoperative indocyanine green angiography for the objective measurement of blood flow
title_fullStr Intraoperative indocyanine green angiography for the objective measurement of blood flow
title_full_unstemmed Intraoperative indocyanine green angiography for the objective measurement of blood flow
title_short Intraoperative indocyanine green angiography for the objective measurement of blood flow
title_sort intraoperative indocyanine green angiography for the objective measurement of blood flow
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865706/
https://www.ncbi.nlm.nih.gov/pubmed/27186573
http://dx.doi.org/10.4174/astr.2016.90.5.279
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