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Changes in inflammatory cytokine networks in myasthenia gravis
Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865732/ https://www.ncbi.nlm.nih.gov/pubmed/27172995 http://dx.doi.org/10.1038/srep25886 |
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author | Uzawa, Akiyuki Kanai, Tetsuya Kawaguchi, Naoki Oda, Fumiko Himuro, Keiichi Kuwabara, Satoshi |
author_facet | Uzawa, Akiyuki Kanai, Tetsuya Kawaguchi, Naoki Oda, Fumiko Himuro, Keiichi Kuwabara, Satoshi |
author_sort | Uzawa, Akiyuki |
collection | PubMed |
description | Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive MG and 25 healthy controls. In patients with MG, serum levels of a proliferation-inducing ligand (APRIL), IL-19, IL-20, IL-28A and IL-35 were significantly increased as compared with controls (p < 0.05). Among them, IL-20, IL-28A and IL-35 were significantly decreased after treatment (p < 0.05). In clinical subtype analyses, APRIL and IL-20 were increased in patients with late-onset MG and IL-28A levels were increased in patients with thymoma-associated MG compared with healthy controls (p < 0.01). The results of the present study demonstrate both anti-inflammatory and inflammatory cytokines are upregulated in MG, reflecting the importance of cytokine-mediated inflammation and its regulation in MG pathophysiology. |
format | Online Article Text |
id | pubmed-4865732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48657322016-05-23 Changes in inflammatory cytokine networks in myasthenia gravis Uzawa, Akiyuki Kanai, Tetsuya Kawaguchi, Naoki Oda, Fumiko Himuro, Keiichi Kuwabara, Satoshi Sci Rep Article Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive MG and 25 healthy controls. In patients with MG, serum levels of a proliferation-inducing ligand (APRIL), IL-19, IL-20, IL-28A and IL-35 were significantly increased as compared with controls (p < 0.05). Among them, IL-20, IL-28A and IL-35 were significantly decreased after treatment (p < 0.05). In clinical subtype analyses, APRIL and IL-20 were increased in patients with late-onset MG and IL-28A levels were increased in patients with thymoma-associated MG compared with healthy controls (p < 0.01). The results of the present study demonstrate both anti-inflammatory and inflammatory cytokines are upregulated in MG, reflecting the importance of cytokine-mediated inflammation and its regulation in MG pathophysiology. Nature Publishing Group 2016-05-13 /pmc/articles/PMC4865732/ /pubmed/27172995 http://dx.doi.org/10.1038/srep25886 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Uzawa, Akiyuki Kanai, Tetsuya Kawaguchi, Naoki Oda, Fumiko Himuro, Keiichi Kuwabara, Satoshi Changes in inflammatory cytokine networks in myasthenia gravis |
title | Changes in inflammatory cytokine networks in myasthenia gravis |
title_full | Changes in inflammatory cytokine networks in myasthenia gravis |
title_fullStr | Changes in inflammatory cytokine networks in myasthenia gravis |
title_full_unstemmed | Changes in inflammatory cytokine networks in myasthenia gravis |
title_short | Changes in inflammatory cytokine networks in myasthenia gravis |
title_sort | changes in inflammatory cytokine networks in myasthenia gravis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865732/ https://www.ncbi.nlm.nih.gov/pubmed/27172995 http://dx.doi.org/10.1038/srep25886 |
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