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Changes in inflammatory cytokine networks in myasthenia gravis

Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive...

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Autores principales: Uzawa, Akiyuki, Kanai, Tetsuya, Kawaguchi, Naoki, Oda, Fumiko, Himuro, Keiichi, Kuwabara, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865732/
https://www.ncbi.nlm.nih.gov/pubmed/27172995
http://dx.doi.org/10.1038/srep25886
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author Uzawa, Akiyuki
Kanai, Tetsuya
Kawaguchi, Naoki
Oda, Fumiko
Himuro, Keiichi
Kuwabara, Satoshi
author_facet Uzawa, Akiyuki
Kanai, Tetsuya
Kawaguchi, Naoki
Oda, Fumiko
Himuro, Keiichi
Kuwabara, Satoshi
author_sort Uzawa, Akiyuki
collection PubMed
description Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive MG and 25 healthy controls. In patients with MG, serum levels of a proliferation-inducing ligand (APRIL), IL-19, IL-20, IL-28A and IL-35 were significantly increased as compared with controls (p < 0.05). Among them, IL-20, IL-28A and IL-35 were significantly decreased after treatment (p < 0.05). In clinical subtype analyses, APRIL and IL-20 were increased in patients with late-onset MG and IL-28A levels were increased in patients with thymoma-associated MG compared with healthy controls (p < 0.01). The results of the present study demonstrate both anti-inflammatory and inflammatory cytokines are upregulated in MG, reflecting the importance of cytokine-mediated inflammation and its regulation in MG pathophysiology.
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spelling pubmed-48657322016-05-23 Changes in inflammatory cytokine networks in myasthenia gravis Uzawa, Akiyuki Kanai, Tetsuya Kawaguchi, Naoki Oda, Fumiko Himuro, Keiichi Kuwabara, Satoshi Sci Rep Article Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive MG and 25 healthy controls. In patients with MG, serum levels of a proliferation-inducing ligand (APRIL), IL-19, IL-20, IL-28A and IL-35 were significantly increased as compared with controls (p < 0.05). Among them, IL-20, IL-28A and IL-35 were significantly decreased after treatment (p < 0.05). In clinical subtype analyses, APRIL and IL-20 were increased in patients with late-onset MG and IL-28A levels were increased in patients with thymoma-associated MG compared with healthy controls (p < 0.01). The results of the present study demonstrate both anti-inflammatory and inflammatory cytokines are upregulated in MG, reflecting the importance of cytokine-mediated inflammation and its regulation in MG pathophysiology. Nature Publishing Group 2016-05-13 /pmc/articles/PMC4865732/ /pubmed/27172995 http://dx.doi.org/10.1038/srep25886 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Uzawa, Akiyuki
Kanai, Tetsuya
Kawaguchi, Naoki
Oda, Fumiko
Himuro, Keiichi
Kuwabara, Satoshi
Changes in inflammatory cytokine networks in myasthenia gravis
title Changes in inflammatory cytokine networks in myasthenia gravis
title_full Changes in inflammatory cytokine networks in myasthenia gravis
title_fullStr Changes in inflammatory cytokine networks in myasthenia gravis
title_full_unstemmed Changes in inflammatory cytokine networks in myasthenia gravis
title_short Changes in inflammatory cytokine networks in myasthenia gravis
title_sort changes in inflammatory cytokine networks in myasthenia gravis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865732/
https://www.ncbi.nlm.nih.gov/pubmed/27172995
http://dx.doi.org/10.1038/srep25886
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