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Sodium channel slow inactivation interferes with open channel block

Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents. PEPD mutations also increase resurgent currents, whi...

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Detalles Bibliográficos
Autores principales:	Hampl, Martin, Eberhardt, Esther, O’Reilly, Andrias O., Lampert, Angelika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865801/ https://www.ncbi.nlm.nih.gov/pubmed/27174182 http://dx.doi.org/10.1038/srep25974

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