Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells

Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Guan, Zhang, Liang, Chen, Xingxing, Xue, Xin, Guo, Qiaonan, Liu, Mingyong, Zhao, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865803/
https://www.ncbi.nlm.nih.gov/pubmed/27173446
http://dx.doi.org/10.1038/srep25946
_version_ 1782431836060778496
author Wang, Guan
Zhang, Liang
Chen, Xingxing
Xue, Xin
Guo, Qiaonan
Liu, Mingyong
Zhao, Jianhua
author_facet Wang, Guan
Zhang, Liang
Chen, Xingxing
Xue, Xin
Guo, Qiaonan
Liu, Mingyong
Zhao, Jianhua
author_sort Wang, Guan
collection PubMed
description Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. Our study demonstrates a unique role of Fpr1 and Fpr2 in NSCs and opens a novel window for cell replacement therapies for brain and spinal cord injury.
format Online
Article
Text
id pubmed-4865803
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48658032016-05-23 Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells Wang, Guan Zhang, Liang Chen, Xingxing Xue, Xin Guo, Qiaonan Liu, Mingyong Zhao, Jianhua Sci Rep Article Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. Our study demonstrates a unique role of Fpr1 and Fpr2 in NSCs and opens a novel window for cell replacement therapies for brain and spinal cord injury. Nature Publishing Group 2016-05-13 /pmc/articles/PMC4865803/ /pubmed/27173446 http://dx.doi.org/10.1038/srep25946 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Guan
Zhang, Liang
Chen, Xingxing
Xue, Xin
Guo, Qiaonan
Liu, Mingyong
Zhao, Jianhua
Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells
title Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells
title_full Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells
title_fullStr Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells
title_full_unstemmed Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells
title_short Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells
title_sort formylpeptide receptors promote the migration and differentiation of rat neural stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865803/
https://www.ncbi.nlm.nih.gov/pubmed/27173446
http://dx.doi.org/10.1038/srep25946
work_keys_str_mv AT wangguan formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells
AT zhangliang formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells
AT chenxingxing formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells
AT xuexin formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells
AT guoqiaonan formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells
AT liumingyong formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells
AT zhaojianhua formylpeptidereceptorspromotethemigrationanddifferentiationofratneuralstemcells

Ejemplares similares