Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis

Heterologous prime–boosting has emerged as a powerful vaccination approach against tuberculosis. However, optimal timing to boost BCG-immunity using subunit vaccines remains unclear in clinical trials. Here, we followed the adhesin Apa-specific T-cell responses in BCG-primed mice and investigated it...

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Detalles Bibliográficos
Autores principales: Nandakumar, Subhadra, Kannanganat, Sunil, Dobos, Karen M., Lucas, Megan, Spencer, John S., Amara, Rama Rao, Plikaytis, Bonnie B., Posey, James E., Sable, Suraj B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865829/
https://www.ncbi.nlm.nih.gov/pubmed/27173443
http://dx.doi.org/10.1038/srep25837

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