A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human...

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Detalles Bibliográficos
Autores principales: Karlas, Alexander, Berre, Stefano, Couderc, Thérèse, Varjak, Margus, Braun, Peter, Meyer, Michael, Gangneux, Nicolas, Karo-Astover, Liis, Weege, Friderike, Raftery, Martin, Schönrich, Günther, Klemm, Uwe, Wurzlbauer, Anne, Bracher, Franz, Merits, Andres, Meyer, Thomas F., Lecuit, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865845/
https://www.ncbi.nlm.nih.gov/pubmed/27177310
http://dx.doi.org/10.1038/ncomms11320

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