Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO(2) extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its princip...

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Detalles Bibliográficos
Autores principales: Van Kanegan, Michael J., Dunn, Denise E., Kaltenbach, Linda S., Shah, Bijal, He, Dong Ning, McCoy, Daniel D., Yang, Peiying, Peng, Jiangnan, Shen, Li, Du, Lin, Cichewicz, Robert H., Newman, Robert A., Lo, Donald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865873/
https://www.ncbi.nlm.nih.gov/pubmed/27172999
http://dx.doi.org/10.1038/srep25626

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