Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of the autism-associated Shank3 g...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoming, Bey, Alexandra L., Katz, Brittany M., Badea, Alexandra, Kim, Namsoo, David, Lisa K., Duffney, Lara J., Kumar, Sunil, Mague, Stephen D., Hulbert, Samuel W., Dutta, Nisha, Hayrapetyan, Volodya, Yu, Chunxiu, Gaidis, Erin, Zhao, Shengli, Ding, Jin-Dong, Xu, Qiong, Chung, Leeyup, Rodriguiz, Ramona M., Wang, Fan, Weinberg, Richard J., Wetsel, William C., Dzirasa, Kafui, Yin, Henry, Jiang, Yong-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866051/
https://www.ncbi.nlm.nih.gov/pubmed/27161151
http://dx.doi.org/10.1038/ncomms11459

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