Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases

Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreo...

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Detalles Bibliográficos
Autores principales: Wang, Yini, Yu, Xiaopeng, Chen, Ermei, Li, Lanuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866276/
https://www.ncbi.nlm.nih.gov/pubmed/27176654
http://dx.doi.org/10.1186/s13287-016-0330-3
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author Wang, Yini
Yu, Xiaopeng
Chen, Ermei
Li, Lanuan
author_facet Wang, Yini
Yu, Xiaopeng
Chen, Ermei
Li, Lanuan
author_sort Wang, Yini
collection PubMed
description Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, anti-inflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases.
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spelling pubmed-48662762016-05-14 Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases Wang, Yini Yu, Xiaopeng Chen, Ermei Li, Lanuan Stem Cell Res Ther Review Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, anti-inflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases. BioMed Central 2016-05-12 /pmc/articles/PMC4866276/ /pubmed/27176654 http://dx.doi.org/10.1186/s13287-016-0330-3 Text en © Wang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Yini
Yu, Xiaopeng
Chen, Ermei
Li, Lanuan
Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
title Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
title_full Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
title_fullStr Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
title_full_unstemmed Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
title_short Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
title_sort liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866276/
https://www.ncbi.nlm.nih.gov/pubmed/27176654
http://dx.doi.org/10.1186/s13287-016-0330-3
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AT lilanuan liverderivedhumanmesenchymalstemcellsanoveltherapeuticsourceforliverdiseases

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