LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias

Levodopa (L-DOPA)-induced dyskinesias (LIDs) represent the major side effect in Parkinson’s disease (PD) therapy. Leucine-rich repeat kinase 2 (LRRK2) mutations account for up to 13 % of familial cases of PD. LRRK2 N-terminal domain encompasses several serine residues that undergo phosphorylation in...

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Detalles Bibliográficos
Autores principales: Stanic, Jennifer, Mellone, Manuela, Cirnaru, Maria Daniela, Perez-Carrion, Maria, Zianni, Elisa, Di Luca, Monica, Gardoni, Fabrizio, Piccoli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866295/
https://www.ncbi.nlm.nih.gov/pubmed/27169991
http://dx.doi.org/10.1186/s13041-016-0234-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866295/
https://www.ncbi.nlm.nih.gov/pubmed/27169991
http://dx.doi.org/10.1186/s13041-016-0234-2

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