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LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias

Levodopa (L-DOPA)-induced dyskinesias (LIDs) represent the major side effect in Parkinson’s disease (PD) therapy. Leucine-rich repeat kinase 2 (LRRK2) mutations account for up to 13 % of familial cases of PD. LRRK2 N-terminal domain encompasses several serine residues that undergo phosphorylation in...

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Detalles Bibliográficos
Autores principales:	Stanic, Jennifer, Mellone, Manuela, Cirnaru, Maria Daniela, Perez-Carrion, Maria, Zianni, Elisa, Di Luca, Monica, Gardoni, Fabrizio, Piccoli, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866295/ https://www.ncbi.nlm.nih.gov/pubmed/27169991 http://dx.doi.org/10.1186/s13041-016-0234-2

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