Circulating tumor DNA in hepatocellular carcinoma: trends and challenges

Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early det...

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Autores principales: Tang, Jia-Cheng, Feng, Yi-Li, Guo, Tao, Xie, An-Yong, Cai, Xiu-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866298/
https://www.ncbi.nlm.nih.gov/pubmed/27182434
http://dx.doi.org/10.1186/s13578-016-0100-z
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author Tang, Jia-Cheng
Feng, Yi-Li
Guo, Tao
Xie, An-Yong
Cai, Xiu-Jun
author_facet Tang, Jia-Cheng
Feng, Yi-Li
Guo, Tao
Xie, An-Yong
Cai, Xiu-Jun
author_sort Tang, Jia-Cheng
collection PubMed
description Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early detection and precision treatment as well as prognosis of hepatocellular carcinoma (HCC). As ctDNA in HCC patients harbors the molecular characteristics of HCC tumor cells, ctDNA analysis in the blood may be sufficient for convenient, non-invasive and accurate detection, providing information for HCC diagnosis, treatment and prognosis. In this review, we will summarize and discuss current trends and challenges of ctDNA application in HCC.
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spelling pubmed-48662982016-05-14 Circulating tumor DNA in hepatocellular carcinoma: trends and challenges Tang, Jia-Cheng Feng, Yi-Li Guo, Tao Xie, An-Yong Cai, Xiu-Jun Cell Biosci Review Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early detection and precision treatment as well as prognosis of hepatocellular carcinoma (HCC). As ctDNA in HCC patients harbors the molecular characteristics of HCC tumor cells, ctDNA analysis in the blood may be sufficient for convenient, non-invasive and accurate detection, providing information for HCC diagnosis, treatment and prognosis. In this review, we will summarize and discuss current trends and challenges of ctDNA application in HCC. BioMed Central 2016-05-11 /pmc/articles/PMC4866298/ /pubmed/27182434 http://dx.doi.org/10.1186/s13578-016-0100-z Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tang, Jia-Cheng
Feng, Yi-Li
Guo, Tao
Xie, An-Yong
Cai, Xiu-Jun
Circulating tumor DNA in hepatocellular carcinoma: trends and challenges
title Circulating tumor DNA in hepatocellular carcinoma: trends and challenges
title_full Circulating tumor DNA in hepatocellular carcinoma: trends and challenges
title_fullStr Circulating tumor DNA in hepatocellular carcinoma: trends and challenges
title_full_unstemmed Circulating tumor DNA in hepatocellular carcinoma: trends and challenges
title_short Circulating tumor DNA in hepatocellular carcinoma: trends and challenges
title_sort circulating tumor dna in hepatocellular carcinoma: trends and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866298/
https://www.ncbi.nlm.nih.gov/pubmed/27182434
http://dx.doi.org/10.1186/s13578-016-0100-z
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