Small non-coding RNA biomarkers in sputum for lung cancer diagnosis

The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA (snoRNA) biomarkers that can potentially be used for noni...

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Autores principales: Su, Yun, Guarnera, Maria A., Fang, HongBin, Jiang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866414/
https://www.ncbi.nlm.nih.gov/pubmed/27176474
http://dx.doi.org/10.1186/s12943-016-0520-8
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author Su, Yun
Guarnera, Maria A.
Fang, HongBin
Jiang, Feng
author_facet Su, Yun
Guarnera, Maria A.
Fang, HongBin
Jiang, Feng
author_sort Su, Yun
collection PubMed
description The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA (snoRNA) biomarkers that can potentially be used for noninvasively diagnosing lung cancer. Here we evaluate the individual and combined applications of the two types of biomarkers in different sets of lung cancer patients and controls. Combined analysis of the miRNAs and snoRNAs has a synergistic effect with 89 % sensitivity and 89 % specificity, and may provide a useful tool for lung cancer early detection.
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spelling pubmed-48664142016-05-14 Small non-coding RNA biomarkers in sputum for lung cancer diagnosis Su, Yun Guarnera, Maria A. Fang, HongBin Jiang, Feng Mol Cancer Letter to the Editor The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA (snoRNA) biomarkers that can potentially be used for noninvasively diagnosing lung cancer. Here we evaluate the individual and combined applications of the two types of biomarkers in different sets of lung cancer patients and controls. Combined analysis of the miRNAs and snoRNAs has a synergistic effect with 89 % sensitivity and 89 % specificity, and may provide a useful tool for lung cancer early detection. BioMed Central 2016-05-12 /pmc/articles/PMC4866414/ /pubmed/27176474 http://dx.doi.org/10.1186/s12943-016-0520-8 Text en © Su et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Su, Yun
Guarnera, Maria A.
Fang, HongBin
Jiang, Feng
Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
title Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
title_full Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
title_fullStr Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
title_full_unstemmed Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
title_short Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
title_sort small non-coding rna biomarkers in sputum for lung cancer diagnosis
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866414/
https://www.ncbi.nlm.nih.gov/pubmed/27176474
http://dx.doi.org/10.1186/s12943-016-0520-8
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