Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis

CONTEXT: Lyme arthritis, a manifestation of tick-borne Lyme disease, can prove to be refractory to classic treatment. CASE REPORT: We present a case of a 48-year-old male, diagnosed with chronic Lyme arthritis, refractory to recurrent and prolonged courses of doxycycline, ceftriaxone, as well as hyd...

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Autores principales: Hirsch, Julianna, Rosner, Itzhak, Rimar, Doron, Kaly, Lisa, Rozenbaum, Michael, Boulman, Nina, Slobodin, Gleb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866477/
https://www.ncbi.nlm.nih.gov/pubmed/27213145
http://dx.doi.org/10.4103/1947-2714.179960
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author Hirsch, Julianna
Rosner, Itzhak
Rimar, Doron
Kaly, Lisa
Rozenbaum, Michael
Boulman, Nina
Slobodin, Gleb
author_facet Hirsch, Julianna
Rosner, Itzhak
Rimar, Doron
Kaly, Lisa
Rozenbaum, Michael
Boulman, Nina
Slobodin, Gleb
author_sort Hirsch, Julianna
collection PubMed
description CONTEXT: Lyme arthritis, a manifestation of tick-borne Lyme disease, can prove to be refractory to classic treatment. CASE REPORT: We present a case of a 48-year-old male, diagnosed with chronic Lyme arthritis, refractory to recurrent and prolonged courses of doxycycline, ceftriaxone, as well as hydroxychloroquine and methotrexate. The patient responded partially to tumor necrosis factor (TNF)-alpha blockade by etanercept and, finally, entered long-term remission after his treatment was switched to tocilizumab. CONCLUSION: Off label treatment by biologic disease modifying antirheumatic drugs can be considered in selected patients with severe antibiotic-resistant Lyme arthritis.C.
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spelling pubmed-48664772016-05-20 Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis Hirsch, Julianna Rosner, Itzhak Rimar, Doron Kaly, Lisa Rozenbaum, Michael Boulman, Nina Slobodin, Gleb N Am J Med Sci Case Report CONTEXT: Lyme arthritis, a manifestation of tick-borne Lyme disease, can prove to be refractory to classic treatment. CASE REPORT: We present a case of a 48-year-old male, diagnosed with chronic Lyme arthritis, refractory to recurrent and prolonged courses of doxycycline, ceftriaxone, as well as hydroxychloroquine and methotrexate. The patient responded partially to tumor necrosis factor (TNF)-alpha blockade by etanercept and, finally, entered long-term remission after his treatment was switched to tocilizumab. CONCLUSION: Off label treatment by biologic disease modifying antirheumatic drugs can be considered in selected patients with severe antibiotic-resistant Lyme arthritis.C. Medknow Publications & Media Pvt Ltd 2016-04 /pmc/articles/PMC4866477/ /pubmed/27213145 http://dx.doi.org/10.4103/1947-2714.179960 Text en This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Hirsch, Julianna
Rosner, Itzhak
Rimar, Doron
Kaly, Lisa
Rozenbaum, Michael
Boulman, Nina
Slobodin, Gleb
Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis
title Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis
title_full Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis
title_fullStr Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis
title_full_unstemmed Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis
title_short Tocilizumab Efficacy in a Patient with Positive Anti-CCP Chronic Lyme Arthritis
title_sort tocilizumab efficacy in a patient with positive anti-ccp chronic lyme arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866477/
https://www.ncbi.nlm.nih.gov/pubmed/27213145
http://dx.doi.org/10.4103/1947-2714.179960
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