Phosphatidylserine exposure is required for ADAM17 sheddase function

ADAM17, a prominent member of the ‘Disintegrin and Metalloproteinase' (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exp...

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Detalles Bibliográficos
Autores principales: Sommer, Anselm, Kordowski, Felix, Büch, Joscha, Maretzky, Thorsten, Evers, Astrid, Andrä, Jörg, Düsterhöft, Stefan, Michalek, Matthias, Lorenzen, Inken, Somasundaram, Prasath, Tholey, Andreas, Sönnichsen, Frank D., Kunzelmann, Karl, Heinbockel, Lena, Nehls, Christian, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866515/
https://www.ncbi.nlm.nih.gov/pubmed/27161080
http://dx.doi.org/10.1038/ncomms11523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866515/
https://www.ncbi.nlm.nih.gov/pubmed/27161080
http://dx.doi.org/10.1038/ncomms11523

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