EnABLing microprocessor for apoptosis

The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1...

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Detalles Bibliográficos
Autores principales: Tu, Chi-Chiang, Wang, Jean Y. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866609/
https://www.ncbi.nlm.nih.gov/pubmed/27182551
http://dx.doi.org/10.1080/23723556.2015.1081860
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author Tu, Chi-Chiang
Wang, Jean Y. J.
author_facet Tu, Chi-Chiang
Wang, Jean Y. J.
author_sort Tu, Chi-Chiang
collection PubMed
description The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1 (ABL) phosphorylates DGCR8 to stimulate the cleavage of a subset of pro-apoptotic pri-miRNAs, thus expanding the nuclear functions of ABL to include regulation of RNA processing.
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spelling pubmed-48666092016-12-08 EnABLing microprocessor for apoptosis Tu, Chi-Chiang Wang, Jean Y. J. Mol Cell Oncol Commentary The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1 (ABL) phosphorylates DGCR8 to stimulate the cleavage of a subset of pro-apoptotic pri-miRNAs, thus expanding the nuclear functions of ABL to include regulation of RNA processing. Taylor & Francis 2015-12-08 /pmc/articles/PMC4866609/ /pubmed/27182551 http://dx.doi.org/10.1080/23723556.2015.1081860 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Tu, Chi-Chiang
Wang, Jean Y. J.
EnABLing microprocessor for apoptosis
title EnABLing microprocessor for apoptosis
title_full EnABLing microprocessor for apoptosis
title_fullStr EnABLing microprocessor for apoptosis
title_full_unstemmed EnABLing microprocessor for apoptosis
title_short EnABLing microprocessor for apoptosis
title_sort enabling microprocessor for apoptosis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866609/
https://www.ncbi.nlm.nih.gov/pubmed/27182551
http://dx.doi.org/10.1080/23723556.2015.1081860
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