Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys

To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using the hM4Di-DREADD (Designer Receptor Exclusively Activated by Designer Drug). Repeated inactivation reduced sensitivity to differenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Eldridge, Mark A G, Lerchner, Walter, Saunders, Richard C, Kaneko, Hiroyuki, Krausz, Kristopher W, Gonzalez, Frank J, Ji, Bin, Higuchi, Makoto, Minamimoto, Takafumi, Richmond, Barry J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866611/
https://www.ncbi.nlm.nih.gov/pubmed/26656645
http://dx.doi.org/10.1038/nn.4192
_version_ 1782431941987926016
author Eldridge, Mark A G
Lerchner, Walter
Saunders, Richard C
Kaneko, Hiroyuki
Krausz, Kristopher W
Gonzalez, Frank J
Ji, Bin
Higuchi, Makoto
Minamimoto, Takafumi
Richmond, Barry J
author_facet Eldridge, Mark A G
Lerchner, Walter
Saunders, Richard C
Kaneko, Hiroyuki
Krausz, Kristopher W
Gonzalez, Frank J
Ji, Bin
Higuchi, Makoto
Minamimoto, Takafumi
Richmond, Barry J
author_sort Eldridge, Mark A G
collection PubMed
description To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using the hM4Di-DREADD (Designer Receptor Exclusively Activated by Designer Drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. Results suggest that retrieval of relative stimulus values from memory appears to depend on interaction between Rh and OFC.
format Online
Article
Text
id pubmed-4866611
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-48666112016-06-14 Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys Eldridge, Mark A G Lerchner, Walter Saunders, Richard C Kaneko, Hiroyuki Krausz, Kristopher W Gonzalez, Frank J Ji, Bin Higuchi, Makoto Minamimoto, Takafumi Richmond, Barry J Nat Neurosci Article To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using the hM4Di-DREADD (Designer Receptor Exclusively Activated by Designer Drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. Results suggest that retrieval of relative stimulus values from memory appears to depend on interaction between Rh and OFC. 2015-12-14 2016-01 /pmc/articles/PMC4866611/ /pubmed/26656645 http://dx.doi.org/10.1038/nn.4192 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Eldridge, Mark A G
Lerchner, Walter
Saunders, Richard C
Kaneko, Hiroyuki
Krausz, Kristopher W
Gonzalez, Frank J
Ji, Bin
Higuchi, Makoto
Minamimoto, Takafumi
Richmond, Barry J
Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
title Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
title_full Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
title_fullStr Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
title_full_unstemmed Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
title_short Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys
title_sort disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using dreadds in rhesus monkeys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866611/
https://www.ncbi.nlm.nih.gov/pubmed/26656645
http://dx.doi.org/10.1038/nn.4192
work_keys_str_mv AT eldridgemarkag disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT lerchnerwalter disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT saundersrichardc disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT kanekohiroyuki disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT krauszkristopherw disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT gonzalezfrankj disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT jibin disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT higuchimakoto disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT minamimototakafumi disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys
AT richmondbarryj disruptionofrelativerewardvaluebyreversibledisconnectionoforbitofrontalandrhinalcortexusingdreaddsinrhesusmonkeys

Ejemplares similares