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Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers
This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866614/ https://www.ncbi.nlm.nih.gov/pubmed/27015139 http://dx.doi.org/10.1080/03601234.2016.1142748 |
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author | Chang, Ellen T. Delzell, Elizabeth |
author_facet | Chang, Ellen T. Delzell, Elizabeth |
author_sort | Chang, Ellen T. |
collection | PubMed |
description | This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically significant for the association between any versus no use of glyphosate and risk of NHL (meta-RR = 1.3, 95% confidence interval (CI) = 1.0–1.6, based on six studies) and MM (meta-RR = 1.4, 95% CI = 1.0–1.9; four studies). Associations were statistically null for HL (meta-RR = 1.1, 95% CI = 0.7–1.6; two studies), leukemia (meta-RR = 1.0, 95% CI = 0.6–1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding may account for observed associations. Meta-analysis is constrained by few studies and a crude exposure metric, while the overall body of literature is methodologically limited and findings are not strong or consistent. Thus, a causal relationship has not been established between glyphosate exposure and risk of any type of LHC. |
format | Online Article Text |
id | pubmed-4866614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48666142016-05-23 Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers Chang, Ellen T. Delzell, Elizabeth J Environ Sci Health B Articles This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically significant for the association between any versus no use of glyphosate and risk of NHL (meta-RR = 1.3, 95% confidence interval (CI) = 1.0–1.6, based on six studies) and MM (meta-RR = 1.4, 95% CI = 1.0–1.9; four studies). Associations were statistically null for HL (meta-RR = 1.1, 95% CI = 0.7–1.6; two studies), leukemia (meta-RR = 1.0, 95% CI = 0.6–1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding may account for observed associations. Meta-analysis is constrained by few studies and a crude exposure metric, while the overall body of literature is methodologically limited and findings are not strong or consistent. Thus, a causal relationship has not been established between glyphosate exposure and risk of any type of LHC. Taylor & Francis 2016-06-02 2016-03-25 /pmc/articles/PMC4866614/ /pubmed/27015139 http://dx.doi.org/10.1080/03601234.2016.1142748 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Articles Chang, Ellen T. Delzell, Elizabeth Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
title | Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
title_full | Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
title_fullStr | Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
title_full_unstemmed | Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
title_short | Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
title_sort | systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866614/ https://www.ncbi.nlm.nih.gov/pubmed/27015139 http://dx.doi.org/10.1080/03601234.2016.1142748 |
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