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Condylomata lata on the ankle: an unusual location

A 43-year-old Japanese man presented with reddish nodules on the ankle. The nodules had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at the periphery and some glomerular vessels in the center and a whitish-pink network, which corresponded to capillary dilatatio...

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Autores principales: Ikeda, Eri, Goto, Akane, Suzaki, Reiko, Sawada, Mizuki, Dekio, Itaru, Ishizaki, Sumiko, Fujibayashi, Mariko, Takahashi, Hayato, Tanaka, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Derm101.com 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866627/
https://www.ncbi.nlm.nih.gov/pubmed/27222772
http://dx.doi.org/10.5826/dpc.0602a09
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author Ikeda, Eri
Goto, Akane
Suzaki, Reiko
Sawada, Mizuki
Dekio, Itaru
Ishizaki, Sumiko
Fujibayashi, Mariko
Takahashi, Hayato
Tanaka, Masaru
author_facet Ikeda, Eri
Goto, Akane
Suzaki, Reiko
Sawada, Mizuki
Dekio, Itaru
Ishizaki, Sumiko
Fujibayashi, Mariko
Takahashi, Hayato
Tanaka, Masaru
author_sort Ikeda, Eri
collection PubMed
description A 43-year-old Japanese man presented with reddish nodules on the ankle. The nodules had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at the periphery and some glomerular vessels in the center and a whitish-pink network, which corresponded to capillary dilatation in the papillary dermis and prominent acanthosis, respectively. These structures were surrounded by a yellowish peripheral structureless area and multiple white, small, round structures in the center, corresponding to the macerated horny layer and keratin plugs. Blood samples were positive for rapid plasma reagin (1:64), Treponema pallidum hemagglutination assay (1:20480), and fluorescent treponemal antibody-absorption (1:1280). A lesional skin biopsy specimen showed irregular acanthosis and papillomatosis. The Warthin-Starry and anti-Treponema pallidum antibody stains on the biopsy specimen revealed many spirochetes in the lower epidermis and the papillary dermis. A diagnosis of secondary syphilis with condylomata lata was made. After one week of treatment with oral benzylpenicillin benzathine hydrate (Bicillin(®) G granules 400,000 units; Banyu Pharmaceutical Co., Ltd, Tokyo, Japan), 1.6 million units (U) daily, the ankle lesions had resolved with a small ulcer and pigmentation. Although syphilis is a relatively common disease, this case study reports an unusual presentation as well as dermoscopy findings.
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spelling pubmed-48666272016-05-24 Condylomata lata on the ankle: an unusual location Ikeda, Eri Goto, Akane Suzaki, Reiko Sawada, Mizuki Dekio, Itaru Ishizaki, Sumiko Fujibayashi, Mariko Takahashi, Hayato Tanaka, Masaru Dermatol Pract Concept Observation A 43-year-old Japanese man presented with reddish nodules on the ankle. The nodules had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at the periphery and some glomerular vessels in the center and a whitish-pink network, which corresponded to capillary dilatation in the papillary dermis and prominent acanthosis, respectively. These structures were surrounded by a yellowish peripheral structureless area and multiple white, small, round structures in the center, corresponding to the macerated horny layer and keratin plugs. Blood samples were positive for rapid plasma reagin (1:64), Treponema pallidum hemagglutination assay (1:20480), and fluorescent treponemal antibody-absorption (1:1280). A lesional skin biopsy specimen showed irregular acanthosis and papillomatosis. The Warthin-Starry and anti-Treponema pallidum antibody stains on the biopsy specimen revealed many spirochetes in the lower epidermis and the papillary dermis. A diagnosis of secondary syphilis with condylomata lata was made. After one week of treatment with oral benzylpenicillin benzathine hydrate (Bicillin(®) G granules 400,000 units; Banyu Pharmaceutical Co., Ltd, Tokyo, Japan), 1.6 million units (U) daily, the ankle lesions had resolved with a small ulcer and pigmentation. Although syphilis is a relatively common disease, this case study reports an unusual presentation as well as dermoscopy findings. Derm101.com 2016-04-30 /pmc/articles/PMC4866627/ /pubmed/27222772 http://dx.doi.org/10.5826/dpc.0602a09 Text en ©2016 Ikeda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Observation
Ikeda, Eri
Goto, Akane
Suzaki, Reiko
Sawada, Mizuki
Dekio, Itaru
Ishizaki, Sumiko
Fujibayashi, Mariko
Takahashi, Hayato
Tanaka, Masaru
Condylomata lata on the ankle: an unusual location
title Condylomata lata on the ankle: an unusual location
title_full Condylomata lata on the ankle: an unusual location
title_fullStr Condylomata lata on the ankle: an unusual location
title_full_unstemmed Condylomata lata on the ankle: an unusual location
title_short Condylomata lata on the ankle: an unusual location
title_sort condylomata lata on the ankle: an unusual location
topic Observation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866627/
https://www.ncbi.nlm.nih.gov/pubmed/27222772
http://dx.doi.org/10.5826/dpc.0602a09
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