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Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

Bifunctional dihydrofolate reductase–thymidylate synthase (DHFR-TS) is a chemically and genetically validated target in African trypanosomes, causative agents of sleeping sickness in humans and nagana in cattle. Here we report the kinetic properties and sensitivity of recombinant enzyme to a range o...

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Detalles Bibliográficos
Autores principales:	Gibson, Marc W., Dewar, Simon, Ong, Han B., Sienkiewicz, Natasha, Fairlamb, Alan H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866688/ https://www.ncbi.nlm.nih.gov/pubmed/27175479 http://dx.doi.org/10.1371/journal.pntd.0004714

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