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Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central step which links cytosolic and mitochondrial intermediary metabolism. To investigate the role of the MPC in mammalian physiology and development, we generated a mouse strain with complete loss of MPC1 expressio...

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Detalles Bibliográficos
Autores principales:	Vanderperre, Benoît, Herzig, Sébastien, Krznar, Petra, Hörl, Manuel, Ammar, Zeinab, Montessuit, Sylvie, Pierredon, Sandra, Zamboni, Nicola, Martinou, Jean-Claude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866774/ https://www.ncbi.nlm.nih.gov/pubmed/27176894 http://dx.doi.org/10.1371/journal.pgen.1006056

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