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Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase

Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors, including sitagliptin, exert favourable effects on the vascular endothelium. DPP-4 inhibitors suppress the degradation of glucagon-like peptide-1 (GLP-1), which has been reported to enhance nitric oxide (NO) production. Howev...

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Detalles Bibliográficos
Autores principales:	TANG, SONG-TAO, SU, HUAN, ZHANG, QIU, TANG, HAI-QIN, WANG, CHANG-JIANG, ZHOU, QING, WEI, WEI, ZHU, HUA-QING, WANG, YUAN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866950/ https://www.ncbi.nlm.nih.gov/pubmed/27122056 http://dx.doi.org/10.3892/ijmm.2016.2578

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