Molecular basis underlying resistance to Mps1/TTK inhibitors

Mps1/TTK is a dual-specificity kinase, with an essential role in mitotic checkpoint signaling, which has emerged as a potential target in cancer therapy. Several Mps1/TTK small-molecule inhibitors have been described that exhibit promising activity in cell culture and xenograft models. Here, we inve...

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Detalles Bibliográficos
Autores principales: Koch, A, Maia, A, Janssen, A, Medema, R H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867491/
https://www.ncbi.nlm.nih.gov/pubmed/26364596
http://dx.doi.org/10.1038/onc.2015.319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867491/
https://www.ncbi.nlm.nih.gov/pubmed/26364596
http://dx.doi.org/10.1038/onc.2015.319

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