Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported recurrent DDX3X mutations in numerous tumors including medulloblastoma (MB), but the physio...

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Detalles Bibliográficos
Autores principales: Valentin-Vega, Yasmine A., Wang, Yong-Dong, Parker, Matthew, Patmore, Deanna M., Kanagaraj, Anderson, Moore, Jennifer, Rusch, Michael, Finkelstein, David, Ellison, David W., Gilbertson, Richard J., Zhang, Jinghui, Kim, Hong Joo, Taylor, J. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867597/
https://www.ncbi.nlm.nih.gov/pubmed/27180681
http://dx.doi.org/10.1038/srep25996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867597/
https://www.ncbi.nlm.nih.gov/pubmed/27180681
http://dx.doi.org/10.1038/srep25996

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