Cargando…
Development of passive CLARITY and immunofluorescent labelling of multiple proteins in human cerebellum: understanding mechanisms of neurodegeneration in mitochondrial disease
CLARITY enables immunofluorescent labelling and imaging of large volumes of tissue to provide a better insight into the three dimensional relationship between cellular morphology and spatial interactions between different cell types. In the current study, we optimise passive CLARITY and immunofluore...
Autores principales: | Phillips, Jonathan, Laude, Alex, Lightowlers, Robert, Morris, Chris M., Turnbull, Doug M., Lax, Nichola Z. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867607/ https://www.ncbi.nlm.nih.gov/pubmed/27181107 http://dx.doi.org/10.1038/srep26013 |
Ejemplares similares
-
The mitochondrial brain: From mitochondrial genome to neurodegeneration
por: Turnbull, Helen E., et al.
Publicado: (2010) -
Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue
por: Grünewald, Anne, et al.
Publicado: (2014) -
Microangiopathy in the cerebellum of patients with mitochondrial DNA disease
por: Lax, Nichola Z., et al.
Publicado: (2012) -
Investigating complex I deficiency in Purkinje cells and synapses in patients with mitochondrial disease
por: Chrysostomou, Alexia, et al.
Publicado: (2015) -
Mitochondrial Mutations: Newly Discovered Players in Neuronal Degeneration
por: Lax, Nichola Z., et al.
Publicado: (2011)