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The G‐protein biased partial κ opioid receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion

BACKGROUND AND PURPOSE: With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs are available since several decades, the incidence of patients that are refractory to medication is still over 30%. Antiepileptic effects of κ opioi...

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Detalles Bibliográficos
Autores principales: Zangrandi, Luca, Burtscher, Johannes, MacKay, James P, Colmers, William F, Schwarzer, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867738/
https://www.ncbi.nlm.nih.gov/pubmed/26928671
http://dx.doi.org/10.1111/bph.13474

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