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Statistical Inference in Hidden Markov Models Using k-Segment Constraints
Hidden Markov models (HMMs) are one of the most widely used statistical methods for analyzing sequence data. However, the reporting of output from HMMs has largely been restricted to the presentation of the most-probable (MAP) hidden state sequence, found via the Viterbi algorithm, or the sequence o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867884/ https://www.ncbi.nlm.nih.gov/pubmed/27226674 http://dx.doi.org/10.1080/01621459.2014.998762 |
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author | Titsias, Michalis K. Holmes, Christopher C. Yau, Christopher |
author_facet | Titsias, Michalis K. Holmes, Christopher C. Yau, Christopher |
author_sort | Titsias, Michalis K. |
collection | PubMed |
description | Hidden Markov models (HMMs) are one of the most widely used statistical methods for analyzing sequence data. However, the reporting of output from HMMs has largely been restricted to the presentation of the most-probable (MAP) hidden state sequence, found via the Viterbi algorithm, or the sequence of most probable marginals using the forward–backward algorithm. In this article, we expand the amount of information we could obtain from the posterior distribution of an HMM by introducing linear-time dynamic programming recursions that, conditional on a user-specified constraint in the number of segments, allow us to (i) find MAP sequences, (ii) compute posterior probabilities, and (iii) simulate sample paths. We collectively call these recursions k-segment algorithms and illustrate their utility using simulated and real examples. We also highlight the prospective and retrospective use of k-segment constraints for fitting HMMs or exploring existing model fits. Supplementary materials for this article are available online. |
format | Online Article Text |
id | pubmed-4867884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48678842016-05-23 Statistical Inference in Hidden Markov Models Using k-Segment Constraints Titsias, Michalis K. Holmes, Christopher C. Yau, Christopher J Am Stat Assoc Theory and Methods Hidden Markov models (HMMs) are one of the most widely used statistical methods for analyzing sequence data. However, the reporting of output from HMMs has largely been restricted to the presentation of the most-probable (MAP) hidden state sequence, found via the Viterbi algorithm, or the sequence of most probable marginals using the forward–backward algorithm. In this article, we expand the amount of information we could obtain from the posterior distribution of an HMM by introducing linear-time dynamic programming recursions that, conditional on a user-specified constraint in the number of segments, allow us to (i) find MAP sequences, (ii) compute posterior probabilities, and (iii) simulate sample paths. We collectively call these recursions k-segment algorithms and illustrate their utility using simulated and real examples. We also highlight the prospective and retrospective use of k-segment constraints for fitting HMMs or exploring existing model fits. Supplementary materials for this article are available online. Taylor & Francis 2016-01-02 2016-05-05 /pmc/articles/PMC4867884/ /pubmed/27226674 http://dx.doi.org/10.1080/01621459.2014.998762 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Theory and Methods Titsias, Michalis K. Holmes, Christopher C. Yau, Christopher Statistical Inference in Hidden Markov Models Using k-Segment Constraints |
title | Statistical Inference in Hidden Markov Models Using k-Segment Constraints |
title_full | Statistical Inference in Hidden Markov Models Using k-Segment Constraints |
title_fullStr | Statistical Inference in Hidden Markov Models Using k-Segment Constraints |
title_full_unstemmed | Statistical Inference in Hidden Markov Models Using k-Segment Constraints |
title_short | Statistical Inference in Hidden Markov Models Using k-Segment Constraints |
title_sort | statistical inference in hidden markov models using k-segment constraints |
topic | Theory and Methods |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867884/ https://www.ncbi.nlm.nih.gov/pubmed/27226674 http://dx.doi.org/10.1080/01621459.2014.998762 |
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