Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals

BACKGROUND: Viral capsid assembly involves the oligomerization of the capsid nucleoprotein (NP), which is an essential step in viral replication and may represent a potential antiviral target. An in vitro transcription-translation reaction using a wheat germ (WG) extract in combination with a sandwi...

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Detalles Bibliográficos
Autores principales: Broce, Sean, Hensley, Lisa, Sato, Tomoharu, Lehrer-Graiwer, Joshua, Essrich, Christian, Edwards, Katie J., Pajda, Jacqueline, Davis, Christopher J., Bhadresh, Rami, Hurt, Clarence R., Freeman, Beverly, Lingappa, Vishwanath R., Kelleher, Colm A., Karpuj, Marcela V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867995/
https://www.ncbi.nlm.nih.gov/pubmed/27179769
http://dx.doi.org/10.1186/s13062-016-0126-5

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