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Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy

PURPOSE: To describe and interpret “choroidal caverns,” an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS: Retrospective analysis of patients with GA. Main outcomes measures included estimation of the p...

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Autores principales: Querques, Giuseppe, Costanzo, Eliana, Miere, Alexandra, Capuano, Vittorio, Souied, Eric H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868100/
https://www.ncbi.nlm.nih.gov/pubmed/27163770
http://dx.doi.org/10.1167/iovs.16-19083
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author Querques, Giuseppe
Costanzo, Eliana
Miere, Alexandra
Capuano, Vittorio
Souied, Eric H.
author_facet Querques, Giuseppe
Costanzo, Eliana
Miere, Alexandra
Capuano, Vittorio
Souied, Eric H.
author_sort Querques, Giuseppe
collection PubMed
description PURPOSE: To describe and interpret “choroidal caverns,” an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS: Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroidal caverns, their localization and relation with retinal-choroidal structures by reviewing medical records and multimodal imaging. RESULTS: One hundred twenty consecutive patients (mean age 80.5 ± 8.61 years) were included. Among the 201 eyes with GA, 17 eyes of 15 patients presented choroidal caverns on OCT B-scan in GA areas (a total of 43 choroidal caverns, mean 2.5/eye, variably localized in the Sattler and Haller layers, with relative preservation of the choriocapillaris). This accounts for 12.5% estimated prevalence (6.5–18.5, 95% confidence interval [CI]) of choroidal caverns in GA areas of atrophic AMD patients. Choroidal caverns appeared on OCT (both B-scan and en face) as gaping hyporeflective cavities in the choroid, typically empty, angular, without hyperreflective borders, often with punctate/linear hyperreflectivities internally. Indocyanine angiography and OCT-Angiography confirmed that the areas occupied by these cavities do not represent perfused choroidal blood vessels. CONCLUSIONS: Choroidal caverns represent a relatively infrequent peculiar finding in GA areas of atrophic AMD eyes. They appear as gaping angular hyporeflective cavities in areas devoid of choroidal vessels, often with punctate/linear hyperreflectivities internally. Choroidal caverns may possibly arise from nonperfused ghost vessels and persistence of stromal pillars where the vessels were originally situated.
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spelling pubmed-48681002016-11-01 Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy Querques, Giuseppe Costanzo, Eliana Miere, Alexandra Capuano, Vittorio Souied, Eric H. Invest Ophthalmol Vis Sci Retina PURPOSE: To describe and interpret “choroidal caverns,” an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS: Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroidal caverns, their localization and relation with retinal-choroidal structures by reviewing medical records and multimodal imaging. RESULTS: One hundred twenty consecutive patients (mean age 80.5 ± 8.61 years) were included. Among the 201 eyes with GA, 17 eyes of 15 patients presented choroidal caverns on OCT B-scan in GA areas (a total of 43 choroidal caverns, mean 2.5/eye, variably localized in the Sattler and Haller layers, with relative preservation of the choriocapillaris). This accounts for 12.5% estimated prevalence (6.5–18.5, 95% confidence interval [CI]) of choroidal caverns in GA areas of atrophic AMD patients. Choroidal caverns appeared on OCT (both B-scan and en face) as gaping hyporeflective cavities in the choroid, typically empty, angular, without hyperreflective borders, often with punctate/linear hyperreflectivities internally. Indocyanine angiography and OCT-Angiography confirmed that the areas occupied by these cavities do not represent perfused choroidal blood vessels. CONCLUSIONS: Choroidal caverns represent a relatively infrequent peculiar finding in GA areas of atrophic AMD eyes. They appear as gaping angular hyporeflective cavities in areas devoid of choroidal vessels, often with punctate/linear hyperreflectivities internally. Choroidal caverns may possibly arise from nonperfused ghost vessels and persistence of stromal pillars where the vessels were originally situated. The Association for Research in Vision and Ophthalmology 2016-05-10 2016-05 /pmc/articles/PMC4868100/ /pubmed/27163770 http://dx.doi.org/10.1167/iovs.16-19083 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Retina
Querques, Giuseppe
Costanzo, Eliana
Miere, Alexandra
Capuano, Vittorio
Souied, Eric H.
Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
title Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
title_full Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
title_fullStr Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
title_full_unstemmed Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
title_short Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
title_sort choroidal caverns: a novel optical coherence tomography finding in geographic atrophy
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868100/
https://www.ncbi.nlm.nih.gov/pubmed/27163770
http://dx.doi.org/10.1167/iovs.16-19083
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