Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone

Pathogenic factors associated with aging, such as oxidative stress and hormone depletion converge on mitochondria and impair their function via opening of the mitochondrial permeability transition pore (MPTP). The MPTP is a large non-selective pore regulated by cyclophilin D (CypD) that disrupts mit...

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Detalles Bibliográficos
Autores principales: Shum, Laura C., White, Noelle S, Nadtochiy, Sergiy M., Bentley, Karen L. de Mesy, Brookes, Paul S, Jonason, Jennifer H., Eliseev, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868300/
https://www.ncbi.nlm.nih.gov/pubmed/27183225
http://dx.doi.org/10.1371/journal.pone.0155709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868300/
https://www.ncbi.nlm.nih.gov/pubmed/27183225
http://dx.doi.org/10.1371/journal.pone.0155709

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