Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints

Structural restrictions are present even in the most sequence diverse portions of antibodies, the complementary determining region (CDR) loops. Previous studies identified robust rules that define canonical structures for five of the six CDR loops, however the heavy chain CDR 3 (HCDR3) defies standa...

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Detalles Bibliográficos
Autores principales: Finn, Jessica A., Koehler Leman, Julia, Willis, Jordan R., Cisneros, Alberto, Crowe, James E., Meiler, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868311/
https://www.ncbi.nlm.nih.gov/pubmed/27182833
http://dx.doi.org/10.1371/journal.pone.0154811

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