Cargando…

α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism

Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient absorption through regulation of gastrointestinal mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khalifeh-Soltani, Amin, Ha, Arnold, Podolsky, Michael J, McCarthy, Donald A, McKleroy, William, Azary, Saeedeh, Sakuma, Stephen, Tharp, Kevin M, Wu, Nanyan, Yokosaki, Yasuyuki, Hart, Daniel, Stahl, Andreas, Atabai, Kamran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868538/ https://www.ncbi.nlm.nih.gov/pubmed/27092791 http://dx.doi.org/10.7554/eLife.13063

Ejemplares similares

MFGE8 inhibits insulin signaling through PTP1B
por: Datta, Ritwik, et al.
Publicado: (2023)

Functional genomic screen identifies novel mediators of collagen uptake
por: Lee, Ting-Hein, et al.
Publicado: (2014)

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes
por: Datta, Ritwik, et al.
Publicado: (2023)

Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits
por: Nishimichi, Norihisa, et al.
Publicado: (2015)

Mfge8 attenuates human gastric antrum smooth muscle contractions
por: Li, Wen, et al.
Publicado: (2021)

New Therapeutic Targets for Hepatic Fibrosis in the Integrin Family, α8β1 and α11β1, Induced Specifically on Activated Stellate Cells
por: Yokosaki, Yasuyuki, et al.
Publicado: (2021)

CARMAL Is a Long Non-coding RNA Locus That Regulates MFGE8 Expression
por: Soubeyrand, Sébastien, et al.
Publicado: (2020)

Intrasphincteric Botulinum Toxin Injection in Treatment of Chronic Idiopathic Constipation in Children
por: Ahmadi, Javad, et al.
Publicado: (2013)

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8
por: Kranich, Jan, et al.
Publicado: (2008)

MFGE8 Does Not Influence Chorio-Retinal Homeostasis or Choroidal Neovascularization in vivo
por: Raoul, William, et al.
Publicado: (2012)

Milk Fat Globule Epidermal Growth Factor 8 (MFGE8) Gene Variants in Rheumatoid Arthritis and Sjögren’s Syndrome
por: Skarlis, Charalampos, et al.
Publicado: (2022)

Identification of MFGE8 in mesenchymal stem cell secretome as an anti-fibrotic factor in liver fibrosis
por: Jang, Yu Jin, et al.
Publicado: (2017)

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
por: Ruotsalainen, Sanni E., et al.
Publicado: (2022)

Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition
por: Tian, Jun, et al.
Publicado: (2021)

Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis
por: Nishimichi, Norihisa, et al.
Publicado: (2021)

Dissecting Heterogeneity Reveals a Unique BAMBI(high)MFGE8(high) Subpopulation of Human UC‐MSCs
por: Chen, Hongwei, et al.
Publicado: (2022)

MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology
por: Psaraki, Adriana, et al.
Publicado: (2023)

Treating COVID-19: Evolving approaches to evidence in a pandemic
por: Lee, Cheryl K., et al.
Publicado: (2022)

Polymorphisms of MFGE8 are associated with susceptibility and clinical manifestations through gene expression modulation in Koreans with systemic lupus erythematosus
por: Baek, Wook-Young, et al.
Publicado: (2019)

Transcriptome Analysis Reveals MFGE8-HAPLN3 Fusion as a Novel Biomarker in Triple-Negative Breast Cancer
por: Wang, Meng-Yuan, et al.
Publicado: (2021)

MFGE8, ALB, APOB, APOE, SAA1, A2M, and C3 as Novel Biomarkers for Stress Cardiomyopathy
por: Pan, Xiao-Yu, et al.
Publicado: (2020)

MFGE8 is down‐regulated in cardiac fibrosis and attenuates endothelial‐mesenchymal transition through Smad2/3‐Snail signalling pathway
por: Wang, Bo, et al.
Publicado: (2020)

TGF-β Increases MFGE8 Production in Myeloid-Derived Suppressor Cells to Promote B16F10 Melanoma Metastasis
por: Lim, Heejin, et al.
Publicado: (2021)

Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells
por: Luo, Liwen, et al.
Publicado: (2023)

Radial glia promote microglial development through integrin α(V)β(8) -TGFβ1 signaling
por: McKinsey, Gabriel L., et al.
Publicado: (2023)

CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis
por: Wu, Yan, et al.
Publicado: (2023)

Potential influences of expression levels of MFGE8 and HMGB1 on the intestinal mucosal barrier function and inflammatory response after blunt abdominal injury in rats
por: Tao, Lijun, et al.
Publicado: (2022)

Human Keratinocyte-Derived Exosomal MALAT1 Promotes Diabetic Wound Healing by Upregulating MFGE8 via microRNA-1914-3p
por: Kuang, Liwen, et al.
Publicado: (2023)

New Blocking Antibodies Impede Adhesion, Migration and Survival of Ovarian Cancer Cells, Highlighting MFGE8 as a Potential Therapeutic Target of Human Ovarian Carcinoma
por: Tibaldi, Lorenzo, et al.
Publicado: (2013)

Camostat mesilate inhibits pro-inflammatory cytokine secretion and improves cell viability by regulating MFGE8 and HMGN1 in lipopolysaccharide-stimulated DF-1 chicken embryo fibroblasts
por: Yuan, Lin, et al.
Publicado: (2021)

A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
por: Marek, Ines, et al.
Publicado: (2020)

Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice
por: Nakagawa, Yoshiko, et al.
Publicado: (2017)

Cancer Prognosis Defined by the Combined Analysis of 8q, PTEN and ERG
por: Silva, Maria P., et al.
Publicado: (2016)

CBX8 interacts with chromatin PTEN and is involved in regulating mitotic progression
por: Choi, Byeong Hyeok, et al.
Publicado: (2021)

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
por: Stupack, Dwayne G., et al.
Publicado: (2001)

Role of integrin alpha8 in murine model of lung fibrosis
por: Hung, Chi F., et al.
Publicado: (2018)

Integrin subunit beta 8 contributes to lenvatinib resistance in HCC
por: Hou, Wei, et al.
Publicado: (2022)

The Changing Integrin Expression and a Role for Integrin β8 in the Chondrogenic Differentiation of Mesenchymal Stem Cells
por: LaPointe, Vanessa L. S., et al.
Publicado: (2013)

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation
por: Bromberger, Thomas, et al.
Publicado: (2022)

Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice
por: Nakagawa, Yoshiko, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_emmesoqf4dks2c1kjjrt4j4vbf