Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

In contrast to many other sarcoma subtypes, the chaotic karyotypes of osteosarcoma have precluded the identification of pathognomonic translocations. We here report hundreds of genomic rearrangements in osteosarcoma cell lines, showing clear characteristics of microhomology-mediated break-induced re...

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Detalles Bibliográficos
Autores principales: Lorenz, Susanne, Barøy, Tale, Sun, Jinchang, Nome, Torfinn, Vodák, Daniel, Bryne, Jan-Christian, Håkelien, Anne-Mari, Fernandez-Cuesta, Lynnette, Möhlendick, Birte, Rieder, Harald, Szuhai, Karoly, Zaikova, Olga, Ahlquist, Terje C., Thomassen, Gard O. S., Skotheim, Rolf I., Lothe, Ragnhild A., Tarpey, Patrick S., Campbell, Peter, Flanagan, Adrienne, Myklebost, Ola, Meza-Zepeda, Leonardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868685/
https://www.ncbi.nlm.nih.gov/pubmed/26672768
http://dx.doi.org/10.18632/oncotarget.6567

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