Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling

PEL is a B-cell non-Hodgkin lymphoma, occurring predominantly as a lymphomatous effusion in body cavities, characterized by aggressive clinical course, with no standard therapy. Based on previous reports that PEL cells display a Warburg phenotype, we hypothesized that the highly hypoxic environment...

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Detalles Bibliográficos
Autores principales: Mediani, Laura, Gibellini, Federica, Bertacchini, Jessika, Frasson, Chiara, Bosco, Raffaella, Accordi, Benedetta, Basso, Giuseppe, Bonora, Massimo, Calabrò, Maria Luisa, Mattiolo, Adriana, Sgarbi, Gianluca, Baracca, Alessandra, Pinton, Paolo, Riva, Giovanni, Rampazzo, Enrico, Petrizza, Luca, Prodi, Luca, Milani, Daniela, Luppi, Mario, Potenza, Leonardo, De Pol, Anto, Cocco, Lucio, Capitani, Silvano, Marmiroli, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868703/
https://www.ncbi.nlm.nih.gov/pubmed/26575168
http://dx.doi.org/10.18632/oncotarget.6315

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