Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

Ki-67 expression is correlated with cell proliferation and is a prognostic marker for various cancers; however, its function is unknown. Here we demonstrate that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cidado, Justin, Wong, Hong Yuen, Rosen, D. Marc, Cimino-Mathews, Ashley, Garay, Joseph P., Fessler, Abigail G., Rasheed, Zeshaan A., Hicks, Jessica, Cochran, Rory L., Croessmann, Sarah, Zabransky, Daniel J., Mohseni, Morassa, Beaver, Julia A., Chu, David, Cravero, Karen, Christenson, Eric S., Medford, Arielle, Mattox, Austin, De Marzo, Angelo M., Argani, Pedram, Chawla, Ajay, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868756/
https://www.ncbi.nlm.nih.gov/pubmed/26823390
http://dx.doi.org/10.18632/oncotarget.7057

Ejemplares similares

Ejemplares similares