A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows

Ovarian follicular cysts are anovulatory follicular structures that lead to infertility. Hormones play key roles in the formation and persistence of cysts. Inhibins are heterodimeric gonadal glycoprotein hormones that belong to the transforming growth factor-β superfamily. These hormones suppress th...

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Autores principales: LI, Wanhong, CHEN, Shuxiong, LI, Hongjiao, LIU, Zhuo, ZHAO, Yun, CHEN, Lu, ZHOU, Xu, LI, Chunjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Theriogenology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868885/
https://www.ncbi.nlm.nih.gov/pubmed/26521695
http://dx.doi.org/10.1292/jvms.14-0489
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author LI, Wanhong
CHEN, Shuxiong
LI, Hongjiao
LIU, Zhuo
ZHAO, Yun
CHEN, Lu
ZHOU, Xu
LI, Chunjing
author_facet LI, Wanhong
CHEN, Shuxiong
LI, Hongjiao
LIU, Zhuo
ZHAO, Yun
CHEN, Lu
ZHOU, Xu
LI, Chunjing
author_sort LI, Wanhong
collection PubMed
description Ovarian follicular cysts are anovulatory follicular structures that lead to infertility. Hormones play key roles in the formation and persistence of cysts. Inhibins are heterodimeric gonadal glycoprotein hormones that belong to the transforming growth factor-β superfamily. These hormones suppress the secretion of follicle-stimulating hormone. In this report, partial fragment of inhibin-α (INHA) subunit gene of Large White pig was detected from the genomic DNA by polymerase chain reaction. The sequence showed a 283 bp fragment insertion/deletion (I/D) polymorphism in INHA subunit gene. A total of 49 Large White sows with cystic follicles and 152 normal sows were screened for this polymorphism. The relationship of INHA I/D polymorphisms with follicular cysts was investigated. The distribution of I/D was significantly different between cystic and normal sows, thereby suggesting that the INHA subunit gene might be a potential biological marker for breeding programs in pig.
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spelling pubmed-48688852016-05-17 A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows LI, Wanhong CHEN, Shuxiong LI, Hongjiao LIU, Zhuo ZHAO, Yun CHEN, Lu ZHOU, Xu LI, Chunjing J Vet Med Sci Theriogenology Ovarian follicular cysts are anovulatory follicular structures that lead to infertility. Hormones play key roles in the formation and persistence of cysts. Inhibins are heterodimeric gonadal glycoprotein hormones that belong to the transforming growth factor-β superfamily. These hormones suppress the secretion of follicle-stimulating hormone. In this report, partial fragment of inhibin-α (INHA) subunit gene of Large White pig was detected from the genomic DNA by polymerase chain reaction. The sequence showed a 283 bp fragment insertion/deletion (I/D) polymorphism in INHA subunit gene. A total of 49 Large White sows with cystic follicles and 152 normal sows were screened for this polymorphism. The relationship of INHA I/D polymorphisms with follicular cysts was investigated. The distribution of I/D was significantly different between cystic and normal sows, thereby suggesting that the INHA subunit gene might be a potential biological marker for breeding programs in pig. The Japanese Society of Veterinary Science 2015-11-02 2016-03 /pmc/articles/PMC4868885/ /pubmed/26521695 http://dx.doi.org/10.1292/jvms.14-0489 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Theriogenology
LI, Wanhong
CHEN, Shuxiong
LI, Hongjiao
LIU, Zhuo
ZHAO, Yun
CHEN, Lu
ZHOU, Xu
LI, Chunjing
A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows
title A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows
title_full A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows
title_fullStr A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows
title_full_unstemmed A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows
title_short A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows
title_sort new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in large white sows
topic Theriogenology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868885/
https://www.ncbi.nlm.nih.gov/pubmed/26521695
http://dx.doi.org/10.1292/jvms.14-0489
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