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Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for geneti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868892/ https://www.ncbi.nlm.nih.gov/pubmed/27243037 http://dx.doi.org/10.1155/2016/8560691 |
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author | Hora, A. S. Tonietti, P. O. Taniwaki, S. A. Asano, K. M. Maiorka, P. Richtzenhain, L. J. Brandão, P. E. |
author_facet | Hora, A. S. Tonietti, P. O. Taniwaki, S. A. Asano, K. M. Maiorka, P. Richtzenhain, L. J. Brandão, P. E. |
author_sort | Hora, A. S. |
collection | PubMed |
description | Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a–c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account. |
format | Online Article Text |
id | pubmed-4868892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48688922016-05-30 Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? Hora, A. S. Tonietti, P. O. Taniwaki, S. A. Asano, K. M. Maiorka, P. Richtzenhain, L. J. Brandão, P. E. Biomed Res Int Research Article Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a–c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account. Hindawi Publishing Corporation 2016 2016-05-03 /pmc/articles/PMC4868892/ /pubmed/27243037 http://dx.doi.org/10.1155/2016/8560691 Text en Copyright © 2016 A. S. Hora et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hora, A. S. Tonietti, P. O. Taniwaki, S. A. Asano, K. M. Maiorka, P. Richtzenhain, L. J. Brandão, P. E. Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? |
title | Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? |
title_full | Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? |
title_fullStr | Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? |
title_full_unstemmed | Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? |
title_short | Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? |
title_sort | feline coronavirus 3c protein: a candidate for a virulence marker? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868892/ https://www.ncbi.nlm.nih.gov/pubmed/27243037 http://dx.doi.org/10.1155/2016/8560691 |
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