Cargando…

Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?

Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for geneti...

Descripción completa

Detalles Bibliográficos
Autores principales: Hora, A. S., Tonietti, P. O., Taniwaki, S. A., Asano, K. M., Maiorka, P., Richtzenhain, L. J., Brandão, P. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868892/
https://www.ncbi.nlm.nih.gov/pubmed/27243037
http://dx.doi.org/10.1155/2016/8560691
_version_ 1782432222605737984
author Hora, A. S.
Tonietti, P. O.
Taniwaki, S. A.
Asano, K. M.
Maiorka, P.
Richtzenhain, L. J.
Brandão, P. E.
author_facet Hora, A. S.
Tonietti, P. O.
Taniwaki, S. A.
Asano, K. M.
Maiorka, P.
Richtzenhain, L. J.
Brandão, P. E.
author_sort Hora, A. S.
collection PubMed
description Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a–c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account.
format Online
Article
Text
id pubmed-4868892
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-48688922016-05-30 Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker? Hora, A. S. Tonietti, P. O. Taniwaki, S. A. Asano, K. M. Maiorka, P. Richtzenhain, L. J. Brandão, P. E. Biomed Res Int Research Article Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a–c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account. Hindawi Publishing Corporation 2016 2016-05-03 /pmc/articles/PMC4868892/ /pubmed/27243037 http://dx.doi.org/10.1155/2016/8560691 Text en Copyright © 2016 A. S. Hora et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hora, A. S.
Tonietti, P. O.
Taniwaki, S. A.
Asano, K. M.
Maiorka, P.
Richtzenhain, L. J.
Brandão, P. E.
Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
title Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
title_full Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
title_fullStr Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
title_full_unstemmed Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
title_short Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
title_sort feline coronavirus 3c protein: a candidate for a virulence marker?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868892/
https://www.ncbi.nlm.nih.gov/pubmed/27243037
http://dx.doi.org/10.1155/2016/8560691
work_keys_str_mv AT horaas felinecoronavirus3cproteinacandidateforavirulencemarker
AT toniettipo felinecoronavirus3cproteinacandidateforavirulencemarker
AT taniwakisa felinecoronavirus3cproteinacandidateforavirulencemarker
AT asanokm felinecoronavirus3cproteinacandidateforavirulencemarker
AT maiorkap felinecoronavirus3cproteinacandidateforavirulencemarker
AT richtzenhainlj felinecoronavirus3cproteinacandidateforavirulencemarker
AT brandaope felinecoronavirus3cproteinacandidateforavirulencemarker