Cargando…
Managing Sleep Disturbances in Cirrhosis
Sleep disturbances, particularly daytime sleepiness and insomnia, are common problems reported by patients suffering from liver cirrhosis. Poor sleep negatively impacts patients' quality of life and cognitive functions and increases mortality. Although sleep disturbances can be an early sign of...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868900/ https://www.ncbi.nlm.nih.gov/pubmed/27242950 http://dx.doi.org/10.1155/2016/6576812 |
_version_ | 1782432224481640448 |
---|---|
author | Zhao, Xun Wong, Philip |
author_facet | Zhao, Xun Wong, Philip |
author_sort | Zhao, Xun |
collection | PubMed |
description | Sleep disturbances, particularly daytime sleepiness and insomnia, are common problems reported by patients suffering from liver cirrhosis. Poor sleep negatively impacts patients' quality of life and cognitive functions and increases mortality. Although sleep disturbances can be an early sign of hepatic encephalopathy (HE), many patients without HE still complain of poor quality sleep. The pathophysiology of these disturbances is not fully understood but is believed to be linked to impaired hepatic melatonin metabolism. This paper provides an overview for the clinician of common comorbidities contributing to poor sleep in patients with liver disease, mainly restless leg syndrome and obstructive sleep apnea. It discusses nondrug and pharmacologic treatment options in these patients, such as the use of light therapy and histamine (H1) blockers. |
format | Online Article Text |
id | pubmed-4868900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48689002016-05-30 Managing Sleep Disturbances in Cirrhosis Zhao, Xun Wong, Philip Scientifica (Cairo) Review Article Sleep disturbances, particularly daytime sleepiness and insomnia, are common problems reported by patients suffering from liver cirrhosis. Poor sleep negatively impacts patients' quality of life and cognitive functions and increases mortality. Although sleep disturbances can be an early sign of hepatic encephalopathy (HE), many patients without HE still complain of poor quality sleep. The pathophysiology of these disturbances is not fully understood but is believed to be linked to impaired hepatic melatonin metabolism. This paper provides an overview for the clinician of common comorbidities contributing to poor sleep in patients with liver disease, mainly restless leg syndrome and obstructive sleep apnea. It discusses nondrug and pharmacologic treatment options in these patients, such as the use of light therapy and histamine (H1) blockers. Hindawi Publishing Corporation 2016 2016-05-03 /pmc/articles/PMC4868900/ /pubmed/27242950 http://dx.doi.org/10.1155/2016/6576812 Text en Copyright © 2016 X. Zhao and P. Wong. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhao, Xun Wong, Philip Managing Sleep Disturbances in Cirrhosis |
title | Managing Sleep Disturbances in Cirrhosis |
title_full | Managing Sleep Disturbances in Cirrhosis |
title_fullStr | Managing Sleep Disturbances in Cirrhosis |
title_full_unstemmed | Managing Sleep Disturbances in Cirrhosis |
title_short | Managing Sleep Disturbances in Cirrhosis |
title_sort | managing sleep disturbances in cirrhosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868900/ https://www.ncbi.nlm.nih.gov/pubmed/27242950 http://dx.doi.org/10.1155/2016/6576812 |
work_keys_str_mv | AT zhaoxun managingsleepdisturbancesincirrhosis AT wongphilip managingsleepdisturbancesincirrhosis |