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Managing Sleep Disturbances in Cirrhosis

Sleep disturbances, particularly daytime sleepiness and insomnia, are common problems reported by patients suffering from liver cirrhosis. Poor sleep negatively impacts patients' quality of life and cognitive functions and increases mortality. Although sleep disturbances can be an early sign of...

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Detalles Bibliográficos
Autores principales: Zhao, Xun, Wong, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868900/
https://www.ncbi.nlm.nih.gov/pubmed/27242950
http://dx.doi.org/10.1155/2016/6576812
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author Zhao, Xun
Wong, Philip
author_facet Zhao, Xun
Wong, Philip
author_sort Zhao, Xun
collection PubMed
description Sleep disturbances, particularly daytime sleepiness and insomnia, are common problems reported by patients suffering from liver cirrhosis. Poor sleep negatively impacts patients' quality of life and cognitive functions and increases mortality. Although sleep disturbances can be an early sign of hepatic encephalopathy (HE), many patients without HE still complain of poor quality sleep. The pathophysiology of these disturbances is not fully understood but is believed to be linked to impaired hepatic melatonin metabolism. This paper provides an overview for the clinician of common comorbidities contributing to poor sleep in patients with liver disease, mainly restless leg syndrome and obstructive sleep apnea. It discusses nondrug and pharmacologic treatment options in these patients, such as the use of light therapy and histamine (H1) blockers.
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spelling pubmed-48689002016-05-30 Managing Sleep Disturbances in Cirrhosis Zhao, Xun Wong, Philip Scientifica (Cairo) Review Article Sleep disturbances, particularly daytime sleepiness and insomnia, are common problems reported by patients suffering from liver cirrhosis. Poor sleep negatively impacts patients' quality of life and cognitive functions and increases mortality. Although sleep disturbances can be an early sign of hepatic encephalopathy (HE), many patients without HE still complain of poor quality sleep. The pathophysiology of these disturbances is not fully understood but is believed to be linked to impaired hepatic melatonin metabolism. This paper provides an overview for the clinician of common comorbidities contributing to poor sleep in patients with liver disease, mainly restless leg syndrome and obstructive sleep apnea. It discusses nondrug and pharmacologic treatment options in these patients, such as the use of light therapy and histamine (H1) blockers. Hindawi Publishing Corporation 2016 2016-05-03 /pmc/articles/PMC4868900/ /pubmed/27242950 http://dx.doi.org/10.1155/2016/6576812 Text en Copyright © 2016 X. Zhao and P. Wong. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhao, Xun
Wong, Philip
Managing Sleep Disturbances in Cirrhosis
title Managing Sleep Disturbances in Cirrhosis
title_full Managing Sleep Disturbances in Cirrhosis
title_fullStr Managing Sleep Disturbances in Cirrhosis
title_full_unstemmed Managing Sleep Disturbances in Cirrhosis
title_short Managing Sleep Disturbances in Cirrhosis
title_sort managing sleep disturbances in cirrhosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868900/
https://www.ncbi.nlm.nih.gov/pubmed/27242950
http://dx.doi.org/10.1155/2016/6576812
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