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Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term surv...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868914/ https://www.ncbi.nlm.nih.gov/pubmed/27242906 http://dx.doi.org/10.1155/2016/4956063 |
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author | Nowakowski, Adam Walczak, Piotr Lukomska, Barbara Janowski, Miroslaw |
author_facet | Nowakowski, Adam Walczak, Piotr Lukomska, Barbara Janowski, Miroslaw |
author_sort | Nowakowski, Adam |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies. |
format | Online Article Text |
id | pubmed-4868914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48689142016-05-30 Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival Nowakowski, Adam Walczak, Piotr Lukomska, Barbara Janowski, Miroslaw Stem Cells Int Review Article Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies. Hindawi Publishing Corporation 2016 2016-05-03 /pmc/articles/PMC4868914/ /pubmed/27242906 http://dx.doi.org/10.1155/2016/4956063 Text en Copyright © 2016 Adam Nowakowski et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nowakowski, Adam Walczak, Piotr Lukomska, Barbara Janowski, Miroslaw Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival |
title | Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival |
title_full | Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival |
title_fullStr | Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival |
title_full_unstemmed | Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival |
title_short | Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival |
title_sort | genetic engineering of mesenchymal stem cells to induce their migration and survival |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868914/ https://www.ncbi.nlm.nih.gov/pubmed/27242906 http://dx.doi.org/10.1155/2016/4956063 |
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