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Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity

In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compat...

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Autores principales: Jayasooriya, Primali Rukmal, Madawalagamage, Lindumini Nayanahari, Mendis, Balapuwaduge Ranjit Rigorbert Nihal, Lombardi, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868929/
https://www.ncbi.nlm.nih.gov/pubmed/27195266
http://dx.doi.org/10.1159/000444876
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author Jayasooriya, Primali Rukmal
Madawalagamage, Lindumini Nayanahari
Mendis, Balapuwaduge Ranjit Rigorbert Nihal
Lombardi, Tommaso
author_facet Jayasooriya, Primali Rukmal
Madawalagamage, Lindumini Nayanahari
Mendis, Balapuwaduge Ranjit Rigorbert Nihal
Lombardi, Tommaso
author_sort Jayasooriya, Primali Rukmal
collection PubMed
description In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available. Therefore, our cases were diagnosed as monophasic fibrous SS, utilizing a panel of immunohistochemical markers, including cytokeratins, EMA, Bcl-2, and CD99 as positive indicators and CD34, SMA, MYO-D, and S-100 as negative indicators. PAS staining was used to identify glycogen and to exclude spindle cell carcinomas and leiomyosarcoma, while Alcian blue was used to identify myxoid ground substance and to exclude nodular fasciitis. In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa.
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spelling pubmed-48689292016-05-18 Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity Jayasooriya, Primali Rukmal Madawalagamage, Lindumini Nayanahari Mendis, Balapuwaduge Ranjit Rigorbert Nihal Lombardi, Tommaso Dermatopathology (Basel) Case Studies In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available. Therefore, our cases were diagnosed as monophasic fibrous SS, utilizing a panel of immunohistochemical markers, including cytokeratins, EMA, Bcl-2, and CD99 as positive indicators and CD34, SMA, MYO-D, and S-100 as negative indicators. PAS staining was used to identify glycogen and to exclude spindle cell carcinomas and leiomyosarcoma, while Alcian blue was used to identify myxoid ground substance and to exclude nodular fasciitis. In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa. S. Karger AG 2016-03-22 /pmc/articles/PMC4868929/ /pubmed/27195266 http://dx.doi.org/10.1159/000444876 Text en Copyright © 2016 by S. Karger AG, Basel
spellingShingle Case Studies
Jayasooriya, Primali Rukmal
Madawalagamage, Lindumini Nayanahari
Mendis, Balapuwaduge Ranjit Rigorbert Nihal
Lombardi, Tommaso
Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
title Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
title_full Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
title_fullStr Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
title_full_unstemmed Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
title_short Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
title_sort diagnostic approach to synovial sarcoma of the head and neck illustrated by two cases arising in the face and oral cavity
topic Case Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868929/
https://www.ncbi.nlm.nih.gov/pubmed/27195266
http://dx.doi.org/10.1159/000444876
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