Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion

BACKGROUND: TDP-43 is the main protein component of ubiquitinated inclusions in a subgroup of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients. The C9ORF72 hexanucleotide expansion is one of the main mutations associated with TDP-43 pathology in FTLD and ALS....

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Detalles Bibliográficos
Autores principales: Junttila, Anna, Kuvaja, Mari, Hartikainen, Päivi, Siloaho, Maritta, Helisalmi, Seppo, Moilanen, Virpi, Kiviharju, Anna, Jansson, Lilja, Tienari, Pentti J., Remes, Anne Marja, Herukka, Sanna-Kaisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868946/
https://www.ncbi.nlm.nih.gov/pubmed/27195002
http://dx.doi.org/10.1159/000444788

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