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Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse
In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the prom...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869026/ https://www.ncbi.nlm.nih.gov/pubmed/27183959 http://dx.doi.org/10.1038/srep26187 |
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| author | Li, Jie Xia, Wei Su, Xueting Qin, Xingliang Chen, Ying Li, Shaohua Dong, Jie Ding, Hongmei Li, Hui Huang, Aixue Ge, Xingfeng Hou, Lvbin Wang, Chaonan Sun, Leqiao Bai, Chenjun Shen, Xuelian Fang, Tao Liu, Yuanlin Zhang, Yi Zhang, Hongru Zhang, Hongwen Shao, Ningsheng |
| author_facet | Li, Jie Xia, Wei Su, Xueting Qin, Xingliang Chen, Ying Li, Shaohua Dong, Jie Ding, Hongmei Li, Hui Huang, Aixue Ge, Xingfeng Hou, Lvbin Wang, Chaonan Sun, Leqiao Bai, Chenjun Shen, Xuelian Fang, Tao Liu, Yuanlin Zhang, Yi Zhang, Hongru Zhang, Hongwen Shao, Ningsheng |
| author_sort | Li, Jie |
| collection | PubMed |
| description | In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins. |
| format | Online Article Text |
| id | pubmed-4869026 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48690262016-06-01 Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse Li, Jie Xia, Wei Su, Xueting Qin, Xingliang Chen, Ying Li, Shaohua Dong, Jie Ding, Hongmei Li, Hui Huang, Aixue Ge, Xingfeng Hou, Lvbin Wang, Chaonan Sun, Leqiao Bai, Chenjun Shen, Xuelian Fang, Tao Liu, Yuanlin Zhang, Yi Zhang, Hongru Zhang, Hongwen Shao, Ningsheng Sci Rep Article In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins. Nature Publishing Group 2016-05-17 /pmc/articles/PMC4869026/ /pubmed/27183959 http://dx.doi.org/10.1038/srep26187 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Li, Jie Xia, Wei Su, Xueting Qin, Xingliang Chen, Ying Li, Shaohua Dong, Jie Ding, Hongmei Li, Hui Huang, Aixue Ge, Xingfeng Hou, Lvbin Wang, Chaonan Sun, Leqiao Bai, Chenjun Shen, Xuelian Fang, Tao Liu, Yuanlin Zhang, Yi Zhang, Hongru Zhang, Hongwen Shao, Ningsheng Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse |
| title | Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse |
| title_full | Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse |
| title_fullStr | Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse |
| title_full_unstemmed | Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse |
| title_short | Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse |
| title_sort | species-specific mutual regulation of p53 and mir-138 between human, rat and mouse |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869026/ https://www.ncbi.nlm.nih.gov/pubmed/27183959 http://dx.doi.org/10.1038/srep26187 |
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