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Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies
Growing evidence indicates that exposure to organochlorine pesticides (OCPs) could increase non-Hodgkin lymphoma (NHL) risk. However, results from epidemiological studies investigating this association remain controversial. We thus conducted a meta-analysis to quantitatively evaluate the association...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869027/ https://www.ncbi.nlm.nih.gov/pubmed/27185567 http://dx.doi.org/10.1038/srep25768 |
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author | Luo, Dan Zhou, Tingting Tao, Yun Feng, Yaqian Shen, Xiaoli Mei, Surong |
author_facet | Luo, Dan Zhou, Tingting Tao, Yun Feng, Yaqian Shen, Xiaoli Mei, Surong |
author_sort | Luo, Dan |
collection | PubMed |
description | Growing evidence indicates that exposure to organochlorine pesticides (OCPs) could increase non-Hodgkin lymphoma (NHL) risk. However, results from epidemiological studies investigating this association remain controversial. We thus conducted a meta-analysis to quantitatively evaluate the association between OCP exposure and NHL risk. Relevant publications were searched in PubMed, Web of Science, and Embase and identified according to the inclusion criteria. Thirteen studies (6 nested case-control, 1 case-cohort, and 6 case-control) were selected for this meta-analysis. We used odds ratios (ORs) with 95% confidence intervals (CIs) to estimate the relationship between OCPs exposure and NHL risk. The summary OR for included studies was 1.40 (95% CI 1.27 to 1.56). No overall significant heterogeneity in the OR was observed (P(h) = 0.253, I(2) = 12.6%). Furthermore, OR estimates in subgroup analyses were discussed, and strong associations were observed for dichlorodiphenyldichloroethylene (DDE, OR = 1.38, 95% CI 1.14 to 1.66), hexachlorocyclohexane (HCH, OR = 1.42, 95% CI 1.08 to 1.87), chlordane (OR = 1.93, 95% CI 1.51 to 2.48), and hexachlorobenzene (HCB, OR = 1.54, 95% CI 1.20 to 1.99). This meta-analysis had suggested that total OCPs of interest was significantly positively associated with NHL risk. |
format | Online Article Text |
id | pubmed-4869027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48690272016-06-01 Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies Luo, Dan Zhou, Tingting Tao, Yun Feng, Yaqian Shen, Xiaoli Mei, Surong Sci Rep Article Growing evidence indicates that exposure to organochlorine pesticides (OCPs) could increase non-Hodgkin lymphoma (NHL) risk. However, results from epidemiological studies investigating this association remain controversial. We thus conducted a meta-analysis to quantitatively evaluate the association between OCP exposure and NHL risk. Relevant publications were searched in PubMed, Web of Science, and Embase and identified according to the inclusion criteria. Thirteen studies (6 nested case-control, 1 case-cohort, and 6 case-control) were selected for this meta-analysis. We used odds ratios (ORs) with 95% confidence intervals (CIs) to estimate the relationship between OCPs exposure and NHL risk. The summary OR for included studies was 1.40 (95% CI 1.27 to 1.56). No overall significant heterogeneity in the OR was observed (P(h) = 0.253, I(2) = 12.6%). Furthermore, OR estimates in subgroup analyses were discussed, and strong associations were observed for dichlorodiphenyldichloroethylene (DDE, OR = 1.38, 95% CI 1.14 to 1.66), hexachlorocyclohexane (HCH, OR = 1.42, 95% CI 1.08 to 1.87), chlordane (OR = 1.93, 95% CI 1.51 to 2.48), and hexachlorobenzene (HCB, OR = 1.54, 95% CI 1.20 to 1.99). This meta-analysis had suggested that total OCPs of interest was significantly positively associated with NHL risk. Nature Publishing Group 2016-05-17 /pmc/articles/PMC4869027/ /pubmed/27185567 http://dx.doi.org/10.1038/srep25768 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Luo, Dan Zhou, Tingting Tao, Yun Feng, Yaqian Shen, Xiaoli Mei, Surong Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies |
title | Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies |
title_full | Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies |
title_fullStr | Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies |
title_full_unstemmed | Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies |
title_short | Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies |
title_sort | exposure to organochlorine pesticides and non-hodgkin lymphoma: a meta-analysis of observational studies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869027/ https://www.ncbi.nlm.nih.gov/pubmed/27185567 http://dx.doi.org/10.1038/srep25768 |
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