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Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice

BACKGROUND: Lead is an industrial heavy metal that can decrease sperm motility. OBJECTIVE: The aim was to investigate the protective effects of calcium against lead on motility of spermatozoa. MATERIALS AND METHODS: In total 40 adult male Swiss white mice were randomly divided into 5 groups (control...

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Autores principales: Golshan Iranpour, Farhad, Kheiri, Soleiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869154/
https://www.ncbi.nlm.nih.gov/pubmed/27200429
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author Golshan Iranpour, Farhad
Kheiri, Soleiman
author_facet Golshan Iranpour, Farhad
Kheiri, Soleiman
author_sort Golshan Iranpour, Farhad
collection PubMed
description BACKGROUND: Lead is an industrial heavy metal that can decrease sperm motility. OBJECTIVE: The aim was to investigate the protective effects of calcium against lead on motility of spermatozoa. MATERIALS AND METHODS: In total 40 adult male Swiss white mice were randomly divided into 5 groups (control, lead of 1(st) wk, lead of 2(nd) wk, lead/calcium of 1(st )wk and lead/calcium of 2(nd) wk). The lead groups of mice were injected by a single dose of lead acetate (200 mg/kg) intraperitoneally. Lead/calcium groups of mice were injected by a single same dose of lead acetate along with three doses of 80 mg/kg calcium chloride. The control group of mice was injected only with same volume of distilled water through the same route. Mice of 1(st) and 2(nd) wk groups were sacrificed through cervical dislocation one and two weeks after injections respectively. RESULTS: Mean of the progressive motile spermatozoa of cauda epididymis in lead/calcium group of the first week was higher than the lead group of the first week and this difference was significant. There was not any significant difference among weight of testes and epididymides of all groups. CONCLUSION: It can be concluded that calcium can decrease the effects of lead on sperm motility.
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spelling pubmed-48691542016-05-19 Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice Golshan Iranpour, Farhad Kheiri, Soleiman Int J Reprod Biomed Short Communication BACKGROUND: Lead is an industrial heavy metal that can decrease sperm motility. OBJECTIVE: The aim was to investigate the protective effects of calcium against lead on motility of spermatozoa. MATERIALS AND METHODS: In total 40 adult male Swiss white mice were randomly divided into 5 groups (control, lead of 1(st) wk, lead of 2(nd) wk, lead/calcium of 1(st )wk and lead/calcium of 2(nd) wk). The lead groups of mice were injected by a single dose of lead acetate (200 mg/kg) intraperitoneally. Lead/calcium groups of mice were injected by a single same dose of lead acetate along with three doses of 80 mg/kg calcium chloride. The control group of mice was injected only with same volume of distilled water through the same route. Mice of 1(st) and 2(nd) wk groups were sacrificed through cervical dislocation one and two weeks after injections respectively. RESULTS: Mean of the progressive motile spermatozoa of cauda epididymis in lead/calcium group of the first week was higher than the lead group of the first week and this difference was significant. There was not any significant difference among weight of testes and epididymides of all groups. CONCLUSION: It can be concluded that calcium can decrease the effects of lead on sperm motility. Research and Clinical Center for Infertility 2016-02 /pmc/articles/PMC4869154/ /pubmed/27200429 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Golshan Iranpour, Farhad
Kheiri, Soleiman
Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice
title Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice
title_full Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice
title_fullStr Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice
title_full_unstemmed Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice
title_short Coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in Swiss white mice
title_sort coadministration of calcium chloride with lead acetate can improve motility of cauda epididymal spermatozoa in swiss white mice
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869154/
https://www.ncbi.nlm.nih.gov/pubmed/27200429
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